INDIVIDUAL TEST 111
IA-2 Antibodies
Indication
Suspicion of risk of developing type 1 diabetes (T1D, previously known as insulin-dependent diabetes mellitus, IDDM).
Method
ELISA.
Result
The result is given as negative or positive with a value (IU/ml). Negative <10 IU/ml.
Interpretation
IgG antibodies against IA-2 are frequently found in T1D. About 60-70% of young newly diagnosed people have this antibody. If there are antibodies against islet cells, this confirms the T1D diagnosis. The antibodies can often be observed before clinical signs of T1D. At the time of the diagnosis, up to 90% can have antibodies against one or several of the antigens GAD-65, IA-2, or insulin. The percentage of positive patients depends on age (young people have a higher percentage), disease duration (the percentage decreases over time), and ethnic background. Slightly elevated values may occur in autoimmune endocrine diseases, particularly for autoimmune thyroiditis.
Last updated: 2024-07-02
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ENSKILD ANALYS 111
IA-2-antikroppar
Indikation
Misstanke om typ 1 diabetes (T1D).
Metod
ELISA.
Resultat
Svaret anges som negativt eller positivt med värde (IU/ml). Negativt <10 IU/ml.
Tolkning
Antikroppar mot IA-2 (IA2) av IgG klass förekommer vid typ 1 diabetes (T1D). Ungefär 60-70% av unga nydiagnosticerade har denna antikropp. Om det finns antikroppar mot ö-celler så styrker det diagnosen T1D. Antikropparna kan ofta ses före kliniska tecken på T1D. Vid diagnostillfället kan upp till 90% ha antikroppar på ett eller flera av antigenen GAD-65, IA-2 eller insulin. Andelen positiva beror på ålder (unga har högre andel), sjukdomsduration (andelen minskar med tiden) och etnisk bakgrund. Svagt förhöjda värde kan förekomma vid autoimmuna endokrina sjukdomar, speciellt autoimmun thyreoidit.
Senast uppdaterat: 2024-07-02