INDIVIDUAL TEST 111
IA-2 Antibodies
Indication
Suspicion of type 1 diabetes (T1D)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA
Reference interval
< 10 IU/mL
Result
Results are reported as negative or positive with a concentration.
Interpretation
IgG-antibodies against IA-2 is a marker for type 1 diabetes (T1D) and occurs in 60-70% of patients. Usually other autoantibodies associated with T1D can be found simultaneously. Elevated levels, without manifested T1D, may occur in other autoimmune endocrine diseases, in particular autoimmune thyroiditis.
References
- Hill TG, Hill DJ. Int J Mol Sci. 2024 The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes. PMID: 38612880
- Joglekar MV et al. Lancet Diabetes Endocrinol. 2024. Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores. PMID: 38797187
- Phillip M et al. Diabetes Care. 2024. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. PMID: 38912694
Last updated: 2025-12-08
Can't find what you're looking for? We are here to help
ENSKILD ANALYS 111
IA-2-antikroppar
Indikation
Misstanke om typ 1 diabetes (T1D)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
ELISA
Referensintervall
< 10 IU/mL negativt
Resultat
Resultat anges som negativt eller positivt med koncentration.
Tolkning
IgG-antikroppar mot IA-2 är markör för typ 1 diabetes (T1D) och förekommer hos 60-70% vid diagnos. Vanligen kan andra autoantikroppar som är associerade med T1D påvisas samtidigt.. Lätt förhöjda värden, utan manifest T1D, kan förekomma vid andra autoimmuna endokrina sjukdomar, speciellt autoimmun tyreoidit.
Referenser
- Hill TG, Hill DJ. Int J Mol Sci. 2024 The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes. PMID: 38612880
- Joglekar MV et al. Lancet Diabetes Endocrinol. 2024. Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores. PMID: 38797187
- Phillip M et al. Diabetes Care. 2024. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. PMID: 38912694
Senast uppdaterat: 2025-12-08