INDIVIDUAL TEST 111

IA-2 antibodies

IndicationSuspicion of risk of developing type 1 diabetes (T1D, previously known as insulin-dependent diabetes mellitus, IDDM). The marker may be used for early diagnosis of T1D in both young and old people.MethodRadioimmunoprecipitation with recombinant antigen. IA-2 is also called ICA512 and is an unusual member of the protein tyrosine phosphatase (PTP) family. As an amino acid has been changed in the catalytic part, it has no enzymatic function. The molecular weight is 106kD.AnswerThe result is given as negative or positive with units.InterpretationIgG antibodies against IA-2 are frequently found in T1D. About 60-70% of young newly diagnosed people have this antibody. If there are antibodies against islet cells, this confirms the T1D diagnosis. The antibodies can often be observed before clinical signs of T1D. At the time of the diagnosis up to 90% can have antibodies against one or several of the antigens GAD-65, IA-2 or insulin. The percentage of positive patients depends on age (young people have a higher percentage), disease duration (the percentage decreases over time) and ethnic background. Slightly elevated values may occur in autoimmune endocrine diseases, in particular autoimmune thyroiditis.

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Autoimmune diagnostics

ENSKILD ANALYS 111

IA-2-antikroppar

IndikationMisstanke om typ 1 diabetes (T1D).MetodRadioimmunoprecipitation (RIA).SvarSvaret anges som negativt eller positivt med värde.TolkningAntikroppar mot IA-2 (IA2) av IgG klass förekommer vid typ 1 diabetes (T1D). Ungefär 60-70% av unga nydiagnosticerade har denna antikropp. Om det finns antikroppar mot ö-celler så styrker det diagnosen T1D. Antikropparna kan ofta ses före kliniska tecken på T1D. Vid diagnostillfället kan upp till 90% ha antikroppar på ett eller flera av antigenen GAD-65, IA-2 eller insulin. Andelen positiva beror på ålder (unga har högre andel), sjukdomsduration (andelen miskar med tiden) och etnisk bakgrund. Svagt förhöjda värde kan förekomma vid autoimmuna endokrina sjukdomar, speciellt autoimmun threoidit.

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