INDIVIDUAL TEST 113

Zinc transporter 8 (ZnT8) antibodies

IndicationSuspicion of type 1 diabetes (T1D).MethodRadio immunoprecipitation (RIA).AnswerNegative, borderline or positive with a ratio.InterpretationAntibodies against ZnT8 is an independent marker for type 1 diabetes (T1D) and combined with antibodies against GAD-65, insulin, IA-2 and islet cells it gives an improved diagnostic sensitivity. Anti-ZnT8 antibodies can be associated with different clinical phenotypes of T1D compared to anti-GAD-65 or anti-IA-2 antibodies.

ReferenceHan et. al. Am J Transl Res. 2013. PMID: 23724162

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Autoimmune diagnostics

ENSKILD ANALYS 113

Zink transportör 8 (ZnT8) antikroppar

IndikationMisstanke om type 1 diabetes (T1D).

Method

Radioimmunoprecipitering (RIA).

Svar

Negativt, gränsvärde eller positivt med kvot.

Svarstolkning

Antikroppar mot ZnT8 är en oberoende markör för diabetes typ 1 (T1D) och kombineras med antikroppar mot GAD-65, Insulin, IA-2 och ö-celler för att ge en förbättrad diagnostisk sensitivitet. Anti-ZnT8 kan associeras med olika kliniska fenotyper än anti-GAD-65 eller anti-IA-2.

ReferensHan et. al. Am J Transl Res. 2013. PMID: 23724162

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