INDIVIDUAL TEST 117
mGluR1 Antibodies (IgG)
Indication
Suspicion of autoimmune encephalitis or autoimmune cerebellar ataxia
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
<1:10 negative
Result
Results are reported as negative or positive with a titer.
Interpretation
Antibodies against mGluR1 have been described in (paraneoplastic) cerebellar ataxia, but other neurological symptoms may also occur. The antibodies are primarily associated with Hodgkin lymphoma.
References
- Jarius S, Wildemann B. J Neuroinflammation. 2015. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. PMID: 26377085
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Chandler E et al. Child Neurol Open. 2022. A Novel Case of Idiopathic MGluR1 Encephalitis in a Pediatric Patient. PMID: 35497371
- Vinke et al. Autoimmune Encephalitis With mGluR1 Antibodies Presenting With Epilepsy, but Without Cerebellar Signs: A Case Report. Neurol Neuroimmunol Neuroinflamm. 2022 PMID: 35450924
Last updated: 2025-12-05
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ENSKILD ANALYS 117
mGlur1-antikroppar (IgG)
Indikation
Misstanke om autoimmun encefalit eller autoimmun cerebellär ataxi
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
<1:10 negativt
Resultat
Resultat anges som negativt eller positivt med titer.
Tolkning
Antikroppar mot mGluR1 har beskrivits vid (paraneoplastisk) cerebellär ataxi, men även andra neurologiska symtom kan förekomma. Antikropparna är främst associerade med Hodgkin lymfom.
Referenser
- Jarius S, Wildemann B. J Neuroinflammation. 2015. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. PMID: 26377085
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Chandler E et al. Child Neurol Open. 2022. A Novel Case of Idiopathic MGluR1 Encephalitis in a Pediatric Patient. PMID: 35497371
- Vinke AM, Zong S, Janssen JH, Correia-Hoffmann C, Mané-Damas M, Damoiseaux JGMC, de Vries JM, Pröpper D, Molenaar P, Losen M, Martinez Martinez P, Rouhl RPW. Autoimmune Encephalitis With mGluR1 Antibodies Presenting With Epilepsy, but Without Cerebellar Signs: A Case Report. Neurol Neuroimmunol Neuroinflamm. 2022 PMID: 35450924
Senast uppdaterat: 2025-12-05