INDIVIDUAL TEST 118
mGluR5 Antibodies (IgG)
Indication
Suspicion of autoimmune encephalitis
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
<1:10 negative
Result
Results are reported as negative or positive with a titer.
Interpretation
Antibodies against mGluR5 may occur in autoimmune encephalitis characterized by neuropsychiatric symptoms (Ophelia syndrome), and are associated with Hodgkin lymphoma.
References
- Ancona C et al. Front Pediatr. 2022. Autoimmune Encephalitis and Other Neurological Syndromes With Rare Neuronal Surface Antibodies in Children: A Systematic Literature Review. PMID: 35515348
- Spatola M et al. Neurology. 2018. Encephalitis with mGluR5 antibodies: Symptoms and antibody effects. PMID: 29703767
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Salles PA et al. Mov Disord Clin Pract. 2024. mGlur5 Encephalitis Causing Myoclonus-Ataxia Syndrome and Psychosis: A Case Report. PMID: 38923251
Last updated: 2025-12-05
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ENSKILD ANALYS 118
mGlur5-antikroppar (IgG)
Indikation
Misstanke om autoimmun encefalit
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
<1:10 negativt
Resultat
Resultat anges som negativt eller positivt med titer.
Tolkning
Antikroppar mot mGluR5 kan förekomma vid autoimmun encefalit som karakteriseras av neuropsykiatriska symtom (Ophelia syndrom) och är associerat med Hodgkin lymfom.
Referenser
- Ancona C et al. Front Pediatr. 2022. Autoimmune Encephalitis and Other Neurological Syndromes With Rare Neuronal Surface Antibodies in Children: A Systematic Literature Review. PMID: 35515348
- Spatola M et al. Neurology. 2018. Encephalitis with mGluR5 antibodies: Symptoms and antibody effects. PMID: 29703767
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Salles PA et al. Mov Disord Clin Pract. 2024. mGlur5 Encephalitis Causing Myoclonus-Ataxia Syndrome and Psychosis: A Case Report. PMID: 38923251
Senast uppdaterat: 2025-12-05