INDIVIDUAL TEST 140
THSD7A Antibodies (IgG)
Indication
Suspicion of primary membranous nephropathy (PMN).
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Cell-based assay (CBA), Indirect immunofluorescence (IIF)
Reference interval
<1:10 negative
Result
Results are reported as negative or positive. Positive results will be titrated.
Interpretation
Antibodies against THSD7A have been reported to occur in about 10% of the anti-PLA2R negative cases with membranous nephropathy (PMN). The antibodies are primarily IgG4 subclass and have high disease specificity. Antibody titers are associated with disease activity and follow the degree of proteinuria.
References
- Beck LH Jr et al. N Engl J Med. 2009. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. PMID: 19571279
- Ronco P, Debiec H. J Am Soc Nephrol. 2010. Antigen identification in membranous nephropathy moves toward targeted monitoring and new therapy. PMID: 20185638
- Gödel M et al. N Engl J Med. 2015. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. PMID: 25760365
- Tomas NM et al. N Engl J Med. 2014. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. PMID: 25394321
- Ronco P, Debiec H. Lancet. 2015. Pathophysiological advances in membranous nephropathy: time for a shift in patient's care. PMID: 26090644
- Larsen CP et al. Mod Pathol. 2016. THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity. PMID: 26847174
Last updated: 2024-06-26
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ENSKILD ANALYS 140
THSD7A-antikroppar (IgG)
Indikation
Misstanke om primär membranös nefropati (PMN).
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Cell-based assay (CBA), Indirekt immunofluorescens (IIF)
Referensintervall
<1:10 negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras.
Tolkning
Antikroppar mot THSD7A har rapporterats förekomma i ca 10% av anti-PLA2R negativa fall med membranös nefropati (PMN). Antikropparna är främst av IgG4 subklass och har hög sjukdomsspecificitet. Antikroppsnivå är associerad till sjukdomsaktivitet och följer graden av proteinuri.
- Beck LH Jr et al. N Engl J Med. 2009. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. PMID: 19571279
- Ronco P, Debiec H. J Am Soc Nephrol. 2010. Antigen identification in membranous nephropathy moves toward targeted monitoring and new therapy. PMID: 20185638
- Gödel M et al. N Engl J Med. 2015. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. PMID: 25760365
- Tomas NM et al. N Engl J Med. 2014. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. PMID: 25394321
- Ronco P, Debiec H. Lancet. 2015. Pathophysiological advances in membranous nephropathy: time for a shift in patient's care. PMID: 26090644
- Larsen CP et al. Mod Pathol. 2016. THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity. PMID: 26847174
Senast uppdaterat: 2024-06-26