INDIVIDUAL TEST 140

Thrombospondin type 1 domain-containing 7A (THSD7A) antibodies

IndicationSuspicion of primary membranous nephropathy (PMN), previously idiopathic membranous nephropathy (IMN).MethodIndirect immunofluorescence (IIF) with THSD7A transfected cellsAnswerThe result is given as negative or positive. A positive result is followed by a titer.InterpretationAntibodies against THSD7A have been reported to occur in about 10% of the anti-PLA2R negative cases with membranous nephropathy (PMN). The antibodies are primarily of IgG4 subclass and seem to have high disease specificity. Antibody titers also appear to be associated with disease activity and follow the degree of proteinuria.