INDIVIDUAL TEST 240
Streptolysin O Antibodies
Indication
Suspicion of glomerulonephritis
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Agglutination
Reference interval
< 200 IU/mL negative
Result
Results are reported as negative or positive with a concentration.
Interpretation
Antibodies against streptococci can be detected after infection with beta-haemolytic streptococci group A and may be of some value in suspected rheumatic fever, acute post-streptococcal glomerulonephritis (APGN), or erythema nodosum. The antibody levels begin to rise about 1 week after the infection and reach their highest value after 3-5 weeks. Two samples at an interval of at least 4 weeks are recommended to determine the seroconversion. Positive anti-streptolysin-O is found in 80% of patients with rheumatic fever or acute post-streptococcal glomerulonephritis (APGN).
References
- Blyth CC, Robertson PW. Pathology. 2006. Anti-streptococcal antibodies in the diagnosis of acute and post-streptococcal disease: streptokinase versus streptolysin O and deoxyribonuclease B. PMID: 16581656
- Steer AC et al. Clin Vaccine Immunol. 2009. Normal ranges of streptococcal antibody titers are similar whether streptococci are endemic to the setting or not. PMID: 19052157
- Rodriguez-Iturbe B, Musser JM. J Am Soc Nephrol. 2008. The current state of poststreptococcal glomerulonephritis. PMID: 18667731
- Couser WG. Lancet. 1999. Glomerulonephritis. PMID: 10232333
Last updated: 2025-10-10
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ENSKILD ANALYS 240
Streptolysin O-antikroppar
Indikation
Misstanke om glomerulonefrit
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Agglutination
Referensintervall
<200 UI/mL negativt
Resultat
Resultat anges som negativt eller positivt med koncentration.
Tolkning
Antikroppar mot streptokcoker kan påvisas efter infektion med beta-hemolytiska streptokocker grupp A, och vara av visst värde vid misstanke om reumatisk feber, akut post-streptokock glomerulonefrit (APGN) eller erythema nodosum. Antikroppsnivåerna börjar stiga ungefär en vecka efter infektionen och når sitt högsta värde efter 3-5 veckor. Två prov med minst 4 veckors intervall rekommenderas för fastställande av serokonversion. Positiv anti-streptolysin O ses hos 80% av patienter med reumatisk feber eller APGN.
Referenser
- Blyth CC, Robertson PW. Pathology. 2006. Anti-streptococcal antibodies in the diagnosis of acute and post-streptococcal disease: streptokinase versus streptolysin O and deoxyribonuclease B. PMID: 16581656
- Steer AC et al. Clin Vaccine Immunol. 2009. Normal ranges of streptococcal antibody titers are similar whether streptococci are endemic to the setting or not. PMID: 19052157
- Rodriguez-Iturbe B, Musser JM. J Am Soc Nephrol. 2008. The current state of poststreptococcal glomerulonephritis. PMID: 18667731
- Couser WG. Lancet. 1999. Glomerulonephritis. PMID: 10232333
Senast uppdaterat: 2025-10-10