INDIVIDUAL TEST 485
HMGCR Antibodies
Indication
Suspicion of immune-mediated necrotizing myopathy (IMNM). Anti-HMCGR is strongly associated with previous statin therapy.
Method
Quanta Lite HMGCR ELISA
Result
The test result is given as negative or positive with a value. Reference value: Negative <20 U/mL, Positive ≥20 U/mL.
Interpretation
Antibodies against HMG-CoA reductase (HMGCR) are associated with necrotizing autoimmune-myopathy and can be detected in about 25% of these patients. Antibodies against HMGCR are associated with elevated levels of creatine kinase (CK) in blood. Pronounced proximal muscle weakness is typical while lung involvement is less common. Almost half of the cases have previous treatment with statins. The level of anti-HMGCR is well correlated to the muscle strength and level of creatine kinase (CK) in blood.
Anti-HMGCR is usually not detected in healthy subjects or in subjects with other inflammatory and autoimmune diseases.
References
- Musset L et al., J Immunol Res. 2014; 2014:405956. PMID: 24741598
- Allenbach et al, Medicine (Baltimore). 2014 May;93(3):150-7. PMID: 24797170
- Drouot et al, Arthritis Res Ther. 2014 Feb 3;16(1): R39. PMID: 24484965
- Hamann et al. Autoimmun Rev. 2013 Oct;12(12):1177-81. PMID: 23851103
- Mohassel and Mammen, Curr Opin Rheumatol. 2013 Nov;25(6):747-52. PMID: 24061077
- Mammen AL et al., Arthritis Rheum. 2011 Mar;63(3):713-21. PMID: 21360500
- Soininen K et al, Basic Clin Pharmacol Toxicol 2006, 98: 51-4. PMID: 16433891
- Needham M et al, Neuromusclul Disord 2007,17: 194-200. PMID: 17241784
- Grable-Esposito p et al, Muscle Nerve 2010, 41: 185-90. PMID: 19813188
- Mammen AL et al, Arth Care Res 2012, 64:269-72. PMID: 21972203
- Payam Mohassel and Andrew L. Mammen, Journal of Neuromuscular Diseases 2018, 5: 11-20. PMID: 29480216
Last updated: 2024-07-02
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ENSKILD ANALYS 485
HMGCR-antikroppar
Indikation
Misstanke om immunmedierad nekrotiserande myopati (IMNM). Anti-HMCGR är starkt kopplat till föregående statinbehandling.
Metod
Quanta Lite HMGCR ELISA
Resultat
Svaret anges som negativt eller positivt med värde. Referensintervall: Negativ <20 U/mL, Positiv ≥20 U/mL.
Tolkning
Antikroppar mot HMG-CoA-Reduktas (HMGCR) är associerade med nekrotiserande autoimmun myopati och kan påvisas hos ca 25% av dessa patienter. Ofta ses kraftigt förhöjd nivå av kreatin kinas (CK) i blod. Uttalad proximal muskelsvaghet är typiskt medan lungengagemang är mindre vanligt. Nästan hälften av fallen har föregående behandling med statiner. Nivån av anti-HMGCR korrelerar väl till muskelstyrka och nivå av kreatin-kinas (CK) i blod.
Anti-HMGCR påvisas normalt inte hos friska eller hos personer med andra inflammatoriska och autoimmuna sjukdomar.
Referenser
- Musset L et al., J Immunol Res. 2014; 2014:405956. PMID: 24741598
- Allenbach et al, Medicine (Baltimore). 2014 May;93(3):150-7. PMID: 24797170
- Drouot et al, Arthritis Res Ther. 2014 Feb 3;16(1): R39. PMID: 24484965
- Hamann et al. Autoimmun Rev. 2013 Oct;12(12):1177-81. PMID: 23851103
- Mohassel and Mammen, Curr Opin Rheumatol. 2013 Nov;25(6):747-52. PMID: 24061077
- Mammen AL et al., Arthritis Rheum. 2011 Mar;63(3):713-21. PMID: 21360500
- Soininen K et al, Basic Clin Pharmacol Toxicol 2006, 98: 51-4. PMID: 16433891
- Needham M et al, Neuromusclul Disord 2007,17: 194-200. PMID: 17241784
- Grable-Esposito p et al, Muscle Nerve 2010, 41: 185-90. PMID: 19813188
- Mammen AL et al, Arth Care Res 2012, 64:269-72. PMID: 21972203
- Payam Mohassel and Andrew L. Mammen, Journal of Neuromuscular Diseases 2018, 5: 11-20. PMID: 29480216
Senast uppdaterat: 2024-07-02