INDIVIDUAL TEST 485
HMGCR Antibodies
Indication
Suspicion of immune-mediated necrotizing myopathy (IMNM)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA
Reference interval
<20 U/mL negative
Result
Results are reported as negative or positive with a value.
Interpretation
Antibodies against HMG-CoA reductase (HMGCR) are associated with necrotizing autoimmune myopathy, an uncommon but serious condition that can be seen with or without previous statin therapy.
The progression is often subacute with an increasing symmetrical proximal muscle weakness and high levels of creatine kinase (CK) in the blood. Almost half of the cases have previous treatment with statins. The level of anti-HMGCR correlates to the muscle strength and level of CK.
Anti-HMGCR is usually not detected in healthy individuals or in other inflammatory and autoimmune diseases.
References
- Musset L et al. J Immunol Res. 2014. Analysis of autoantibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase using different technologies. PMID: 24741598
- Allenbach Y et al. Medicine (Baltimore). 2014. Anti-HMGCR autoantibodies in European patients with autoimmune necrotizing myopathies: inconstant exposure to statin. PMID: 24797170
- Mohassel P, Mammen AL. J Neuromuscul Dis. 2018. Anti-HMGCR Myopathy. PMID: 29480216
- Kerola AM et al. RMD Open 2025 Predictive value of myositis antibodies: role of semiquantitative classification and positivity for more than one autoantibody. PMID: 39837620
Last updated: 2025-10-10
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ENSKILD ANALYS 485
HMGCR-antikroppar
Indikation
Misstanke om immunmedierad nekrotiserande myopati (IMNM)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
ELISA
Referensintervall
<20 U/mL negativt
Resultat
Resultat anges som negativt eller positivt ett värde.
Tolkning
Antikroppar mot HMG-CoA-Reduktas (HMGCR) är associerade med nekrotiserande autoimmun myopati, ett ovanligt men allvarligt tillstånd som kan ses med eller utan föregående statin-behandling.
Förloppet är ofta subakut med tilltagande symmetrisk proximal muskelsvaghet och höga nivåer av kreatin-kinas (CK) i blod. Nästan hälften av fallen har föregående behandling med statiner. Nivån av anti-HMGCR korrelerar till muskelstyrka och nivå av CK.
Anti-HMGCR påvisas normalt inte hos friska individer eller vid andra inflammatoriska och autoimmuna tillstånd.
Referenser
- Musset L et al. J Immunol Res. 2014. Analysis of autoantibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase using different technologies. PMID: 24741598
- Allenbach Y et al. Medicine (Baltimore). 2014. Anti-HMGCR autoantibodies in European patients with autoimmune necrotizing myopathies: inconstant exposure to statin. PMID: 24797170
- Mohassel P, Mammen AL. J Neuromuscul Dis. 2018. Anti-HMGCR Myopathy. PMID: 29480216
- Kerola AM et al. RMD Open 2025 Predictive value of myositis antibodies: role of semiquantitative classification and positivity for more than one autoantibody. PMID: 39837620
Senast uppdaterat: 2025-10-10