INDIVIDUAL TEST 516
Cardiolipin Antibodies (IgG, IgM)
Indication
Suspicion of primary antiphospholipid syndrome (APS) and systemic lupus erythematous with secondary antiphospholipid syndrome (APS)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA
Reference interval
<12 U/mL negative
Result
Results are reported as negative or positive with a concentration (U/mL).
Interpretation
Elevated levels of IgG and IgM antibodies against Cardiolipin are included in the laboratory criteria of anti-phospholipid syndrome (APS), characterized by thrombotic tendency (arterial and/or venous) and/or pregnancy morbidity (miscarriage/ preeclampsia/ placental insufficiency).
The syndrome is often associated with SLE (secondary APS) but also occurs without signs of inflammatory systemic disease (primary APS). Antibodies of the IgG isotype have higher diagnostic value than antibodies of the IgM isotype. The highest risk for APS is triple positivity, i.e., the presence of antibodies against Cardiolipin in combination with antibodies against Beta-2-Glycoprotein-1 and lupus anticoagulant.
Antibodies against Cardiolipin may also occur transiently in connection with infection.
References
- Barbhaiya M et al. Ann Rheum Dis. 2023. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. PMID: 37640450
- Cabrera-Marante O et al. Front Immunol. 2025. Criteria and non-criteria anti-phospholipid antibodies in the different clinical forms of antiphospholipid syndrome. PMID: 40821829
- Van Hoovels L et al. J Thromb Haemost. 2025. Multicenter study to improve clinical interpretation of anticardiolipin and anti-β2-glycoprotein I antibody test results for diagnosis of antiphospholipid syndrome. PMID: 40383153
Last updated: 2025-12-01
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ENSKILD ANALYS 516
Kardiolipin-antikroppar (IgG, IgM)
Indikation
Misstanke om primär antifosfolipidsyndrom (APS) och systemisk lupus erytematosus
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
ELISA
Referensintervall
<12 U/mL negativt
Resultat
Resultat anges som negativt eller positivt med koncentration (U/mL).
Tolkning
Förhöjda nivåer av IgG- samt IgM-antikroppar mot kardiolipin ingår i laboratoriekriterierna för antifosfolipidsyndrom (APS) som karakteriseras av trombosbenägenhet (arteriell och/eller venös) och/eller graviditetsmorbiditet (missfall/ preeklampsi/ placentainsufficiens).
Syndromet är ofta associerat med SLE (sekundärt APS), men förekommer även utan tecken på inflammatorisk systemsjukdom (primärt APS). Antikroppar av IgG-isotyp har högre diagnostiskt värde än antikroppar av IgM-isotyp. Högst risk för APS utgör trippelpositivitet dvs förekomst av antikroppar mot kardiolipin i kombination med antikroppar mot beta-2-glykoprotein-1 och lupus antikoagulans.
Antikroppar mot kardiolipin kan även förekomma övergående i samband med infektion.
Referenser
- Barbhaiya M et al. Ann Rheum Dis. 2023. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. PMID: 37640450
- Cabrera-Marante O et al. Front Immunol. 2025. Criteria and non-criteria anti-phospholipid antibodies in the different clinical forms of antiphospholipid syndrome. PMID: 40821829
- Van Hoovels L et al. J Thromb Haemost. 2025. Multicenter study to improve clinical interpretation of anticardiolipin and anti-β2-glycoprotein I antibody test results for diagnosis of antiphospholipid syndrome. PMID: 40383153
Senast uppdaterat: 2025-12-01