PANEL 585, 586

Autoimmune Epilepsy

Indication

Suspicion of autoimmune epilepsy 

Panel 585 “Autoimmune epilepsy” 

Panel 586 “Extended test panel for Autoimmune Epilepsy”  

Clinical background

Autoimmune epilepsy is caused by or associated with antibodies and sometimes linked to cancer. In 2017, the International League Against Epilepsy (ILAE) recognized that epilepsy can be a symptom of an immune disorder with seizures as a core symptom. An immune etiology to epilepsy should be considered if epilepsy, of unknown cause, is associated with evidence of autoimmune-mediated central nervous system (CNS) inflammation.  

The clinical picture of autoimmune epilepsy is varying and can present with anything from a simple seizure to severe cases of autoimmune encephalitis.  

The identification of autoimmune epilepsy cases is of importance because many of the affected patients have a favorable prognosis with immunotherapy.  

References

Quek AM. et al., Arch Neurol. 2012 May; 69 (5):582-93. Autoimmune epilepsy: clinical characteristics and response to immunotherapy. 

Brenner T. et al., Epilepsia 2013, 54 (6); 1028-1035Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy.  

Greco A. et al., Autoimmunity Reviews, 2016 March, Volume 15, Issue 3, 221-225Autoimmune epilepsy. 

Bien C. et al., Epilepsy Curr. 2017 May-Jun;17(3):134-141. Autoimmune Epilepsy: Encephalitis with Autoantibodies for Epileptologists. 

Spatola M., Dalmau J., Curr Opinion Neurology 2017 June; 30 (3):345-353Seizures and risk of epilepsy in autoimmune and other inflammatory encephalitis. 

Dubey D. et al., Epilepsy 2017 58 (7) 1181-1189Predictive models in the diagnosis and treatment of autoimmune epilepsy. 

Lindsay M. Higdon, MD, Practical Neurology, OCTOBER 2018Autoimmune Epilepsy - A newly recognized category of epilepsy caused by or associated with antibodies. https://practicalneurology.com/articles/2018-oct/autoimmune-epilepsy 

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Autoimmune diagnostics

PAKET 585, 586

Autoimmun Epilepsi

Indikation 

Misstanke om autoimmun epilepsi 

Paket 585 ”Autoimmun epilepsi” 

Paket 586 ”Utökad analys vid misstänkt Autoimmun epilepsi” 

Klinik

Autoimmun epilepsi orsakas av eller är associerat med förekomst av autoantikroppar och kan vara associerat med cancer. Under 2017 deklarerade International League Against Epilepsy (ILAE) att epilepsi kan vara ett symtom vid underliggande immunmedierad sjukdom. Autoimmun genes bör utredas vid epilepsi som är associerad med tecken på autoimmun inflammation i centrala nervsystemet. 

Den kliniska bilden vid autoimmun epilepsi är bred och kan visa sig som allt från ett enkelt anfall till tecken på allvarlig autoimmun encefalit.  

Diagnostisering av autoimmun epilepsi är viktig eftersom immunterapi kan ha gynnsam effekt.

Referenser 

Quek AM. et al., Arch Neurol. 2012 May; 69 (5):582-93. Autoimmune epilepsy: clinical characteristics and response to immunotherapy. 

Brenner T. et al., Epilepsia 2013, 54 (6); 1028-1035Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy.  

Greco A. et al., Autoimmunity Reviews, 2016 March, Volume 15, Issue 3, 221-225Autoimmune epilepsy. 

Bien C. et al., Epilepsy Curr. 2017 May-Jun;17(3):134-141. Autoimmune Epilepsy: Encephalitis with Autoantibodies for Epileptologists. 

Spatola M., Dalmau J., Curr Opinion Neurology 2017 June; 30 (3):345-353Seizures and risk of epilepsy in autoimmune and other inflammatory encephalitis. 

Dubey D. et al., Epilepsy 2017 58 (7) 1181-1189Predictive models in the diagnosis and treatment of autoimmune epilepsy. 

Lindsay M. Higdon, MD, Practical Neurology, OCTOBER 2018Autoimmune Epilepsy - A newly recognized category of epilepsy caused by or associated with antibodies. https://practicalneurology.com/articles/2018-oct/autoimmune-epilepsy 

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