DIAGNOSTIC TEST 600
Fibrillarin Antibodies
Diagnostic test for antibodies against fibrillarin. For suspicion of scleroderma.
Indication
Suspicion of systemic sclerosis
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
ELISA-based technique (EliA)
Reference interval
<7 U/mL negative, 7-<10 U/mL borderline
Result
Results are reported as negative, borderline or positive with a concentration (U/mL).
Interpretation
Antibodies occur in about 4% of patients with systemic scleroderma, often together with antibodies against centromers, RNA polymerase and Scl-70. They have also been reported in SLE and primary Reynaud’s syndrome. Anti-fibrillarin is more specific for the diffuse version of sclerodermia than the limited version.
References
- Benyamine A et al. Diagnostics (Basel). 2021. Quantification of Antifibrillarin (anti-U3 RNP) Antibodies: A New Insight for Patients with Systemic Sclerosis. PMID: 34207757
- Andraos R et al. Lupus Sci Med. 2022. Autoantibodies associated with systemic sclerosis in three autoimmune diseases imprinted by type I interferon gene dysregulation: a comparison across SLE, primary Sjögren's syndrome and systemic sclerosis. PMID: 36581379
Included in these panels
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How to order
This test is available worldwide for hospitals, clinics, and physicians.
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Print and complete the request form
Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. -
Prepare your samples
Serum: At least 0.5 mL serum (plain serum tubes without additives).
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Send samples and request form
Within Sweden
Samples can be sent at room temperature to:
Envelopes and smaller boxes:
Wieslab AB, Box 50117, 20211 Malmö, Sweden
Larger boxes and frozen samples:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
International
Send samples cold to:
Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden
Last updated: 2026-01-29
