INDIVIDUAL TEST 600

Fibrillarin Antibodies

IndicationSuspicion of scleroderma, differential diagnosis for Raynaud’s phenomenon.MethodPhadia ELIAAnswerThe result is expressed as negative, borderline or positive with a value. InterpretationFibrillarin antibodies occur in about 4% of patients with systemic scleroderma, often together with antibodies against centromeres, RNA-polymerase and Scl-70. It has also been described in SLE and primary Raynaud’s phenomenon. Anti-fibrillarin is more common in patients of African descent than Caucasians. Anti-fibrillarin is more specific for the diffuse form of scleroderma than the limited one.