DIAGNOSTIC TEST 620

Autoimmune Nodopathy/CIDP – Screen IgG

Diagnostic test for antibodies against NF155 (IgG), NF186 (IgG), CNTN1 (IgG), and CASPR1 (IgG). For suspicion of Inflammatory Neuropathy/Autoimmune Nodopathy.

urgent

Available as urgent test with results within 48 h.

Indication

Suspicion of Inflammatory Neuropathy/Autoimmune Nodopathy that is refractory to standard treatment.

Sample material

Serum

  • Minim. volume: 0,5 mL

Transport

Within Sweden

  • room temperature

International

  • cold

Method

Cell-Based Assay (CBA), Indirect immunofluorescence (IIF)

Reference interval

  • <1:10 negative

Result

Results are reported as negative or positive. A positive result is followed by a titer.

Interpretation

Autoimmune nodopathies have until recently been regarded as subgroups of CIDP but are distinct in both disease course and treatment. They are now regarded as separate disorders.

The panel includes the analysis of the following auto-antibodies that may be helpful in the investigation of patients with CIDP-like symptoms:

  • Neurofascin-155 and Neurofascin-186 antibodies (IgG). Neurofascin-155 (NF155) is a paranodal protein, while Neurofascin-186 (NF186) is a protein present in the nodes of Ranvier. IgG antibodies against NF155 and NF186 have been reported in autoimmune nodopathy. The simultaneous presence of antibodies against NF155 and NF186 is seen in pan-neurofascin nodopathy.
  • Contactin-1 antibodies (IgG). Contactin-1 (CNTN1) is a paranodal protein. IgG antibodies against CNTN1 have been reported in autoimmune nodopathy.
  • CASPR1 antibodies (IgG). Contactin-associated protein 1 (CASPR1) is a paranodal protein. IgG antibodies against CASPR1 have been reported in autoimmune nodopathy.

References

  • Van den Bergh PYK et al. J Peripher Nerv Syst. 2021. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force-Second revision. PMID: 34085743
  • Dong M et al. Clin Neurol Neurosurg. 2022. Characterization of the patients with antibodies against nodal-paranodal junction proteins in chronic inflammatory demyelinating polyneuropathy. PMID: 36401951
  • Querol LA et al. Neurotherapeutics. 2022. The Role of the Complement System in Chronic Inflammatory Demyelinating Polyneuropathy: Implications for Complement-Targeted Therapies. PMID: 35378684
  • Cortese A et al. Neurol Neuroimmunol Neuroinflamm. 2019. Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype. PMID: 31753915
  • Delmont E et al. Brain. 2017. Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy. PMID: 28575198
  • Appeltshauser L et al. Brain. 2023. Anti-pan-neurofascin antibodies induce subclass-related complement activation and nodo-paranodal damage. PMID: 36346134

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Read our sampling instructions for more information

Last updated: 2025-08-18