INDIVIDUAL TEST 737
SOX1 Antibodies (IgG)
Indication
Suspicion of paraneoplastic syndrome and neuropathy
Sample material
Serum
CSF
- Minim. volume: 2,0 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Immunoblot
Reference interval
Serum
- <5 negative
CSF
- negative
Result
Serum
- results are reported as negative, borderline, or positive with an intensity value.
CSF
- results are reported as negative, or positive.
Interpretation
Antibodies against SOX1 (anti-glial nuclear antibody, AGNA) are unusual but have been reported to occur in paraneoplastic neuropathy, Lambert-Eaton syndrome, neuropathy and ataxia. SOX1 antibodies are often associated with antibodies against VGCC, Hu, CV2/CRMP5, or amphiphysin. The most common cancer form associated with SOX1 is small-cell lung cancer, but other lung cancer forms have also been reported.
Antibodies against SOX1 are graded as High-risk antibodies with a frequency of >90% of underlying cancer and a positive result yield 3 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
References
- Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
- Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848
Last updated: 2024-10-16
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ENSKILD ANALYS 737
SOX1-antikroppar (IgG)
Indikation
Misstanke om paraneoplastiskt syndrom och neuropati
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 2,0 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Immunoblot
Referensintervall
Serum
- <5 negativt
Likvor
- negativt
Resultat
Serum
- resultat anges som negativt, gränsvärde eller positivt med intensitetsvärde.
Likvor
- resultat anges som negativt eller positivt.
Tolkning
Antikroppar mot SOX1 (anti-glial-nuclear-antibody, AGNA) är ovanliga men har rapporterats förekomma vid paraneoplastisk neuropati, Lambert-Eaton Syndrom och vid neuropati och ataxi. SOX1 antikroppar kan förekomma tillsammans med autoantikroppar mot VGCC, Hu, CV2/CRMP5 eller amfifysin. Den vanligaste cancerformen som är associerad med SOX1 är småcellig lungcancer, men även andra lungcancerformer har rapporterats.
Antikropparna riktade mot SOX1 bedöms vara High-risk antibodies med en förekomst på >90 % för en underliggande cancer och positivitet ger 3 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
Referenser
- Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
- Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848
Senast uppdaterat: 2024-10-16
Mer information
Detta är en ackrediterad analys.> Läs mer [.pdf]
Mer information om provtagning.
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