Vial

INDIVIDUAL TEST 737

SOX1 (anti-glia nuclear antibody) antibodies

Indication Suspicion of paraneoplastic syndrome and ambiguous forms of neuropathy. 

Method Immunoblot. 

Result Serum: The result is reported as negative, borderline or positive with a value (blot intensity). 

CSF: The result is reported as negative, borderline or positive 

Interpretation Antibodies against SOX1 (or anti-glial nuclear antibody, AGNA) are unusual but have been reported to occur in paraneoplastic neuropathy, Lambert-Eaton syndrome and in unclear forms of neuropathy and ataxia. SOX1 antibodies are often associated with antibodies against VGCC, Hu, CV2 / CRMP5 or amphiphysin. The most common cancer form associated with SOX1 is small cell lung cancer, but other lung cancer forms have also been reported. 

Antibodies against SOX1 are graded as Higher-risk antibodies with a frequency of >90% of underlying cancer and a positive result yield 3 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. 

References 
  • Stich O, Klages E, Bischler P, Jarius S, Rasiah C, Voltz R, Rauer S. SOX1 antibodies in sera from patients with paraneoplastic neurological syndromes. Acta Neurol Scand. 2012 May;125(5):326-31. PMID: 21751968. 
  • Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology. 2011 Jul 12;77(2):179-89. PMID: 21747075 
  • Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622 

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Vial

ENSKILD ANALYS 737

SOX1 (anti-glia nuclear antibody) antikroppar

Indikation Misstanke om paraneoplastiska syndrom och oklara former av neuropati. 

Metod Immunoblot. 

Svar Serum: Resultatet anges som negativt, gränsvärde eller positivt med värde (blot intensitet). 

Likvor: Resultatet anges som negativt, gränsvärde eller positivt. 

Tolkning Antikroppar mot SOX1 (anti-glial-nuclear-antibody, AGNA) är ovanliga men har rapporterats förekomma vid paraneoplastisk neuropati, Lambert-Eaton Syndrom och vid oklara former av neuropati och ataxi. SOX1 antikroppar kan förekomma tillsammans med autoantikroppar mot VGCC, Hu, CV2/CRMP5 eller amphiphysin. Den vanligaste cancerformen som är associerad med SOX1 är småcellig lungcancer, men även andra lungcancerformer har rapporterats. 

Antikropparna riktade mot SOX1 bedöms vara Higher-risk antibodies med en förekomst på >90 % för en underliggande cancer och positivitet ger 3 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. 

Referenser 
  • Stich O, Klages E, Bischler P, Jarius S, Rasiah C, Voltz R, Rauer S. SOX1 antibodies in sera from patients with paraneoplastic neurological syndromes. Acta Neurol Scand. 2012 May;125(5):326-31. PMID: 21751968. 
  • Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology. 2011 Jul 12;77(2):179-89. PMID: 21747075 
  • Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622

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