INDIVIDUAL TEST 737

SOX1 (anti-glia nuclear antibody) antibodies

Indication Suspicion of paraneoplastic syndrome and ambiguous forms of neuropathy.

Method Immunoblot.

Answer Serum: The result is reported as negative, borderline or positive with a value (blot intensity).

CSF: The result is reported as negative or positive

Interpretation Antibodies against SOX1 (or anti-glial nuclear antibody, AGNA) are unusual but have been reported to occur in paraneoplastic neuropathy, Lambert-Eaton syndrome and in unclear forms of neuropathy and ataxia. SOX1 antibodies are often associated with antibodies against VGCC, Hu, CV2 / CRMP5 or amphiphysin. The most common cancer form associated with SOX1 is small cell lung cancer, but other lung cancer forms have also been reported.

References

Stich et al. Acta Neurol Scand. 2012;125(5):326-31.

Lancaster et al. Neurology. 2011;12;77(2):179-89. 

Zuliani et al. J Neurol Neurosurg Psychiatry. 2012;83(6):638-45. 

Tschernatsch et al. Autoimmun Rev. 2009 Jun;8(7):549-51.

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Neurology

ENSKILD ANALYS 737

SOX1 (anti-glia nuclear antibody) antikroppar

Indikation Misstanke om paraneoplastiska syndrom och oklara former av neuropati.

Metod Immunoblot.

Svar Serum: Resultatet anges som negativt, gränsvärde eller positivt med värde (blot intensitet).

Likvor: Resultatet anges som negativt eller positivt.

Tolkning Antikroppar mot SOX1 (anti-glial-nuclear-antibody, AGNA) är ovanliga men har rapporterats förekomma vid paraneoplastisk neuropati, Lambert-Eaton Syndrom och vid oklara former av neuropati och ataxi. SOX1 antikroppar kan förekomma tillsammans med autoantikroppar mot VGCC, Hu, CV2/CRMP5 eller amphiphysin. Den vanligaste cancerformen som är associerad med SOX1 är småcellig lungcancer, men även andra lungcancerformer har rapporterats.

Referenser

Stich et al. Acta Neurol Scand. 2012;125(5):326-31.

Lancaster et al. Neurology. 2011;12;77(2):179-89. 

Zuliani et al. J Neurol Neurosurg Psychiatry. 2012;83(6):638-45. 

Tschernatsch et al. Autoimmun Rev. 2009 Jun;8(7):549-51.

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Neurologi