INDIVIDUAL TEST 740
Yo (Purkinje cell) Antibodies (IgG)
Indication
Suspicion of paraneoplastic syndrome
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 2,0 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Immunoblot/Indirect immunofluorescence (IIF)
According to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes, anti-neuronal antibodies should be detected by at least two independent methods to be reliable. At Wieslab IIF and immunoblot are used.
Reference interval
Serum
- Immunoblot: ≤5 negative
- Indirect Immunofluorescence: <1:10 negative
Likvor
- Immunoblot: negative
- Indirect immunofluorescence: negative
Result
Serum
- Immunoblot: results are reported as negative, borderline, or positive with an intensity value.
- Indirect immunofluorescence (IIF): results are reported as negative or positive. Positive results will be titrated.
CSF
- Immunoblot: results are reported as negative, borderline, or positive.
- Indirect immunofluorescence (IIF): results are reported as negative or positive.
Interpretation
Antibodies against Yo are also called anti-PCA-1 (Purkinje cell antigen 1) and are strongly associated with subacute cerebral ataxia and ovarian or breast cancer. Neuropathy may also occur. Neurological symptoms can precede cancer diagnosis by up to 5 years.
Antibodies against Yo are graded as High-risk antibodies with a frequency of >90% of underlying cancer and a positive result yields 3 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
References
- Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
- Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848
Last updated: 2024-10-21
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ENSKILD ANALYS 740
Yo (PCA-1)-antikroppar (IgG)
Indikation
Misstanke om paraneoplastiskt syndrom
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 2,0 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Immunoblot/Indirekt immunofluorescens (IIF)
Enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes ska anti-neuronala antikroppar detekteras med minst två oberoende metoder för att vara tillförlitligt. På Wieslab används IIF och immunoblot.
Referensintervall
Serum
- Immunoblot: ≤5 negativt
- Indirekt Immunofluorescens: <1:10 negativt
Likvor
- Immunoblot: negativt
- Indirekt immunofluorescens: negativt
Resultat
Serum
- Immunoblot: resultat anges som negativt, gränsvärde eller positivt med intensitetsvärde.
- Indirekt immunofluorescens: resultat anges som negativt eller positivt. Positivt resultat titreras.
Likvor
- Immunoblot: resultat anges som negativt, gränsvärde eller positivt.
- Indirekt immunofluorescens: resultat anges som negativt eller positivt.
Tolkning
Antikroppar mot Yo kallas också anti-PCA-1 (Purkinjecellsantigen 1) och är starkt associerade med subakut cerebral ataxi vid ovarial- eller bröstcancer. Neuropati kan också förekomma. Neurologiska symtom kan föregå cancerdiagnos med upp till 5 år. Antikropparna riktade mot Yo bedöms vara High-risk antibodies med en förekomst på >90% för en underliggande cancer och positivitet ger 3 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
Referenser
- Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
- Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848
Senast uppdaterat: 2024-10-21
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Detta är en ackrediterad analys.> Läs mer [.pdf]
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