Vial

INDIVIDUAL TEST 740

Yo (Purkinje cell antibodies)

Indication Suspicion of paraneoplastic syndrome. 

Method Immunoblot and indirect immunofluorescence (IIF).  

According to guidelines, anti-neuronal antibodies should be detected by at least two independent methods. At Wieslab IIF and immunoblot are used. According to European guidelines, a positive result should be obtained with both methods to be reliable 

Result Serum: The result is reported as negative, borderline or positive with a IIF titer and blot intensity. 

CSF: The result is reported as negative, borderline or positive. 

Interpretation Antibodies against Yo are also called anti-PCA-1 (Purkinje cell antigen 1) and are strongly associated to subacute cerebral ataxia and ovarian or breast cancer. Neurological symptoms can precede cancer diagnosis by up to 5 year. 

Antibodies against Yo are graded as High-risk antibodies with a frequency of >90% of underlying cancer and a positive result yield 3 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. 

References 
  • Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology. 2011 Jul 12;77(2):179-89. PMID: 21747075 
  • Balint B, Vincent A, Meinck HM, Irani SR, Bhatia KP. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. Brain. 2018 Jan 1;141(1):13-36. PMID: 29053777 
  • Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622

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Vial

ENSKILD ANALYS 740

Yo (Purkinjecells-antikroppar)

Indikation Misstanke om paraneoplastiska syndrom. 

Metod Immunoblot samt indirekt immunofluorescens (IIF).  

Enligt riktlinjer ska anti-neuronala antikroppar detekteras med minst två oberoende metoder. På Wieslab används IIF och immunoblot. Enligt europeiska riktlinjer ska positivt resultat uppnås med båda metoderna för att vara tillförlitligt.  

Svar Serum: Resultatet anges som negativt, gränsvärde eller positivt med IIF titer och blot intensitet. 

Likvor: Resultatet anges som negativt, gränsvärde eller positivt. 

Tolkning Antikroppar mot Yo kallas också anti-PCA-1 (Purkinjecellsantigen 1) och är starkt associerade med subakut cerebral ataxi vid ovarial- eller bröstcancer. Neuropati kan också förekomma. Neurologiska symtom kan föregå cancerdiagnosen med upp till 5 år. 

Antikropparna riktade mot Yo bedöms vara High-risk antibodies med en förekomst på >90% för en underliggande cancer och positivitet ger 3 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. 

Referenser 
  • Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology. 2011 Jul 12;77(2):179-89. PMID: 21747075 
  • Balint B, Vincent A, Meinck HM, Irani SR, Bhatia KP. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. Brain. 2018 Jan 1;141(1):13-36. PMID: 29053777 
  • Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622 

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