INDIVIDUAL TEST 742
Zic4 Antibodies (IgG)
Indication
Suspicion of paraneoplastic syndrome
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 2,0 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Immunoblot
Reference interval
Serum
- ≤5 negative
CSF
- negative
Result
Serum
- results are reported as negative, borderline, or positive with an intensity value.
CSF
- results are reported as negative, borderline, or positive.
Interpretation
Antibodies against Zic4 may occur with paraneoplastic neurological disease associated with small-cell lung cancer with or without neurological symptoms. Most Zic4-positive patients also produce antibodies against Hu and CV2. Patients who have only Zic4 antibodies usually display symptoms of cerebellar degeneration. Patients with a combination of Zic4 and other autoantibodies suffer from a broader spectrum of symptoms.
References
- Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
- Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848
Last updated: 2024-10-21
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ENSKILD ANALYS 742
Zic4-antikroppar (IgG)
Indikation
Misstanke om paraneoplastiskt syndrom
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 2,0 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Immunoblot
Referensintervall
Serum
- ≤5 negativt
Likvor
- negativt
Resultat
Serum
- resultat anges som negativt, gränsvärde eller positivt med intensitetsvärde.
Likvor
- resultat anges som negativt, gränsvärde eller positivt.
Tolkning
Antikroppar mot Zic4 kan förekomma vid paraneoplastisk neurologisk sjukdom associerad med småcellig lungcancer (SCLC) och även vid SCLC utan neurologiska symptom. De flesta Zic4 positiva patienter har även antikroppar mot t.ex. Hu och CV2. Patienter som endast har Zic4 antikroppar har oftast en ren cerebellär degeneration medan patienter med en kombination av Zic4 och andra autoantikroppar har ett bredare spektrum av symptom.
Referenser
- Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
- Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848
Senast uppdaterat: 2024-10-21
Mer information
Detta är en ackrediterad analys.> Läs mer [.pdf]
Mer information om provtagning.
> Läs mer