INDIVIDUAL TEST 742

Zic4 antibodies

Indication

Suspicion of paraneoplastic syndromes small cell lung cancer (SCLC).

Method Immunoblot. Accredited analysis for serum samples – read more at the Quality page.

Answer Serum: The result is reported as negative, borderline or positive with a value (blot intensity).

CSF: The result is reported as negative, borderline or positive

Interpretation Antibodies against Zic4 may occur with paraneoplastic neurological disease associated to small cell lung cancer with or without neurological symptoms. Most Zic4 positive patients also produce antibodies against Hu and CV2. Patients who have only Zic4 antibodies usually display symptom of cerebellar degeneration. Patients with a combination of Zic4 and other autoantibodies suffers from a broader spectrum of symptoms.

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Neurology

ENSKILD ANALYS 742

Zic4-antikroppar

Indikation Misstanke om paraneoplastiska syndrom småcellig lung cancer (SCLC).

Metod Immunoblot.

Svar Serum: Resultatet anges som negativt, gränsvärde eller positivt med värde (blot intensitet). Likvor: Resultatet anges som negativt, gränsvärde eller positivt.

Tolkning Antikroppar mot Zic4 kan förekomma vid paraneoplastisk neurologisk sjukdom associerad med småcellig lungcancer (SCLC) och även vid SCLC utan associerade neurologiska symptom. Antikroppar mot Zic4 ses ofta i kombination med antikroppar mot t.ex. Hu och CV2. Patienter som endast har Zic4 antikroppar har oftast en ren cerebellär degeneration medan patienter med en kombination av Zic4 och andra autoantikroppar har ett bredare spektrum av symptom.

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Neurologi