INDIVIDUAL TEST 760
Tr Antibodies (IgG)
Indication
Suspicion of paraneoplastic syndrome
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 2,0 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Immunoblot
Reference interval
Serum
- ≤5 negative
CSF
- negative
Result
Serum
- results are reported as negative, borderline, or positive with an intensity value.
CSF
- results are reported as negative, borderline, or positive.
Interpretation
Antibodies against Tr (Trotter antigen, DNER) can be seen in breast or ovarian cancer, small cell lung cancer, thymoma, and Hodgkin's lymphoma and are associated with paraneoplastic encephalomyelitis or cerebellar degeneration.
Antibodies against Tr are graded as High-risk antibodies with a frequency of 90% of underlying cancer and a positive result yields a 3-point PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
References
- Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
- Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848
Last updated: 2024-10-21
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ENSKILD ANALYS 760
Tr-antikroppar (IgG)
Indikation
Misstanke om paraneoplastiskt syndrom
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 2,0 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Immunoblot
Referensintervall
Serum
- ≤5 negativt
Likvor
- negativt
Resultat
Serum
- resultat anges som negativt, gränsvärde eller positivt med intensitetsvärde.
Likvor
- resultat anges som negativt, gränsvärde eller positivt.
Tolkning
Antikroppar mot Tr (Trotter antigen, DNER) kan ses vid bröst- eller ovariecancer, småcellig lungcancer, thymom, samt vid Hodgkins lymfom och är associerade med paraneoplastisk encephalomyelit eller cerebellär degeneration.
Antikropparna riktade mot Tr bedöms vara High-risk antibodies med en förekomst på 90% för en underliggande cancer och positivitet ger 3 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
Referenser
- Rosenfeld MR, Dalmau J. Neurol Clin. 2018. Paraneoplastic Neurologic Syndromes. PMID: 30072076
- Balint B et al. Brain. 2018. Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology. PMID: 29053777
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Garza M, Piquet AL. Front Neurol. 2021. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. PMID: 34489848
Senast uppdaterat: 2024-10-21
Mer information
Detta är en ackrediterad analys.> Läs mer [.pdf]
Mer information om provtagning.
> Läs mer