INDIVIDUAL TEST 805
Plexin D1 Antibodies (IgG)
Indication
Suspicion of small fiber neuropathy (SFN)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Western Blot
Reference interval
Negative
Result
Results are reported as negative or positive.
Interpretation
Antibodies against Plexin D1 can be detected in polyneuropathy patients with sensory polyneuropathy, which is often characterized as burning pain and thermal hyperalgesia.
References
- Fujii T et al. Ann Neurol. 2018. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. PMID: 30014510
- Fujii T et al. Neurol Neuroimmunol Neuroinflamm. 2020. Painful trigeminal neuropathy associated with anti-Plexin D1 antibody. PMID: 32587101
- Zeidman LA. Neurol Clin. 2021. Advances in the Management of Small Fiber Neuropathy. PMID: 33223078
- Morelli L et al. Rev Neurosci. 2024. The role of antibodies in small fiber neuropathy: a review of currently available evidence. PMID: 38865989
Last updated: 2025-10-09
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ENSKILD ANALYS 805
Plexin D1-antikroppar (IgG)
Indikation
Misstanke om fintrådsneuropati (SFN)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Western Blot
Referensintervall
Negativt
Resultat
Resultat anges som negativt eller positivt.
Tolkning
Antikroppar mot Plexin D1 kan detekteras vid sensorisk polyneuropati som ofta karakteriseras av brännande smärta och termisk hyperalgesi.
Referenser
- Fujii T et al. Ann Neurol. 2018. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. PMID: 30014510
- Fujii T et al. Neurol Neuroimmunol Neuroinflamm. 2020. Painful trigeminal neuropathy associated with anti-Plexin D1 antibody. PMID: 32587101
- Zeidman LA. Neurol Clin. 2021. Advances in the Management of Small Fiber Neuropathy. PMID: 33223078
- Morelli L et al. Rev Neurosci. 2024. The role of antibodies in small fiber neuropathy: a review of currently available evidence. PMID: 38865989
Senast uppdaterat: 2025-10-09