INDIVIDUAL TEST 805
Plexin D1 antibodies (IgG)
IndicationSuspicion of small fiber neuropathy.
Method Western blot
Result Results are reported as negative or positive.
Interpretation In a Japanese study of 110 patients with neuropathic pain autoantibodies against Plexin D1 could be detected in sera from about 10% of the cases. The autoantibodies were shown to bind selectively to mouse unmyelinated C-fibers. Burning pain and thermal hyperalgesia was characteristic and patients often responded to immunotherapies.
References
- Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. Ann Neurol. 2018 Aug;84(2):208-224. doi: 10.1002/ana.25279. Epub 2018 Sep 3. PMID: 30014510.
- Fujii T, Yamasaki R, Miyachi Y, Iinuma K, Hashimoto Y, Isobe N, Matsushita T, Kira JI. Painful trigeminal neuropathy associated with anti-Plexin D1 antibody. Neurol Neuroimmunol Neuroinflamm. 2020 Jun 25;7(5):e819. doi: 10.1212/NXI.0000000000000819. PMID: 32587101; PMCID: PMC7357409.
- Zeidman LA. Advances in the Management of Small Fiber Neuropathy. Neurol Clin. 2021 Feb;39(1):113-131. doi: 10.1016/j.ncl.2020.09.006. Epub 2020 Nov 7. PMID: 33223078
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ENSKILD ANALYS 805
Plexin D1-antikroppar (IgG)
Indikation
Misstanke om fintrådsneuropati
Metod
Western Blot
Svar
Svaret anges som negativt eller positivt.
Tolkning
I en japansk studie av 110 patienter med neuropatisk smärta kunde autoantikroppar mot Plexin D1 påvisas i serum hos ca 10%. Autoantikropparna visades binda selektivt till omyeliniserade C-fibrer hos mus. Brännande smärta och thermal hyperalgesi var typisk och patienterna svarade ofta på immunmodulerande behandling.
Referenser
- Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. Ann Neurol. 2018 Aug;84(2):208-224. doi: 10.1002/ana.25279. Epub 2018 Sep 3. PMID: 30014510.
- Fujii T, Yamasaki R, Miyachi Y, Iinuma K, Hashimoto Y, Isobe N, Matsushita T, Kira JI. Painful trigeminal neuropathy associated with anti-Plexin D1 antibody. Neurol Neuroimmunol Neuroinflamm. 2020 Jun 25;7(5):e819. doi: 10.1212/NXI.0000000000000819. PMID: 32587101; PMCID: PMC7357409.
- Zeidman LA. Advances in the Management of Small Fiber Neuropathy. Neurol Clin. 2021 Feb;39(1):113-131. doi: 10.1016/j.ncl.2020.09.006. Epub 2020 Nov 7. PMID: 33223078.