Vial

INDIVIDUAL TEST 805

Plexin D1 antibodies

IndicationSuspicion of small fiber neuropathy. 

Method Western blot 

Result Results are reported as negative or positive. 

Interpretation In a Japanese study of 110 patients with neuropathic pain autoantibodies against Plexin D1 could be detected in sera from about 10% of the cases. The autoantibodies were shown to bind selectively to mouse unmyelinated C-fibers. Burning pain and thermal hyperalgesia was characteristic and patients often responded to immunotherapies. 

References 

  • Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. Ann Neurol. 2018 Aug;84(2):208-224. doi: 10.1002/ana.25279. Epub 2018 Sep 3. PMID: 30014510.
  • Fujii T, Yamasaki R, Miyachi Y, Iinuma K, Hashimoto Y, Isobe N, Matsushita T, Kira JI. Painful trigeminal neuropathy associated with anti-Plexin D1 antibody. Neurol Neuroimmunol Neuroinflamm. 2020 Jun 25;7(5):e819. doi: 10.1212/NXI.0000000000000819. PMID: 32587101; PMCID: PMC7357409. 
  • Zeidman LA. Advances in the Management of Small Fiber Neuropathy. Neurol Clin. 2021 Feb;39(1):113-131. doi: 10.1016/j.ncl.2020.09.006. Epub 2020 Nov 7. PMID: 33223078

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Vial

ENSKILD ANALYS 805

Plexin D1 antikroppar

Indikation

Misstanke om fintrådsneuropati 

Metod

Western Blot 

Svar

Svaret anges som negativt eller positivt. 

Tolkning

I en japansk studie av 110 patienter med neuropatisk smärta kunde autoantikroppar mot Plexin D1 påvisas i serum hos ca 10%. Autoantikropparna visades binda selektivt till omyeliniserade C-fibrer hos mus. Brännande smärta och thermal hyperalgesi var typisk och patienterna svarade ofta på immunmodulerande behandling. 

Referenser 

  • Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. Ann Neurol. 2018 Aug;84(2):208-224. doi: 10.1002/ana.25279. Epub 2018 Sep 3. PMID: 30014510.
  • Fujii T, Yamasaki R, Miyachi Y, Iinuma K, Hashimoto Y, Isobe N, Matsushita T, Kira JI. Painful trigeminal neuropathy associated with anti-Plexin D1 antibody. Neurol Neuroimmunol Neuroinflamm. 2020 Jun 25;7(5):e819. doi: 10.1212/NXI.0000000000000819. PMID: 32587101; PMCID: PMC7357409. 
  • Zeidman LA. Advances in the Management of Small Fiber Neuropathy. Neurol Clin. 2021 Feb;39(1):113-131. doi: 10.1016/j.ncl.2020.09.006. Epub 2020 Nov 7. PMID: 33223078. 

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