INDIVIDUAL TEST 831
VGKC Antibodies (IgG)
Indication
Suspicion of autoimmune encephalitis and paraneoplastic symptoms
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
RIA
Reference interval
Serum: <72 pmol/L negative
CSF: <2 pmol/L negative
Result
Results are reported as negative or positive with a concentration (pmol/L).
Interpretation
Antibodies against potassium channel complex are primarily seen in patients with neuromyotonia, Morvan's syndrome, autoimmune encephalitis, or idiopathic epilepsy. These antibodies are often directed to the potassium channel-associated proteins CASPR2 (contactin-associated protein-2) and LGI1 (leucine-rich, glioma inactivated protein 1), and further analysis of these specificities is recommended.
In serum, the relevance of antibodies with levels below 300 pmol/L is uncertain. In autoimmune encephalitis, the antibody level in serum is often over 300-500 pmol/L.
Last updated: 2025-12-05
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ENSKILD ANALYS 831
VGKC-antikroppar (IgG)
Indikation
Misstanke om autoimmun encefalit och paraneoplastiska symptom
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
RIA
Referensintervall
Serum: <72 pmol/L negativt
Likvor: <2 pmol/L negativt
Resultat
Resultat anges som negativt eller positivt med koncentration (pmol/L).
Tolkning
Antikroppar mot VGKC ses framför allt hos patienter med neuromyotoni, Morvans syndrom, autoimmun encefalit eller idiopatisk epilepsi. Antikropparna är vanligen riktade mot de kaliumkanal-associerade proteinerna CASPR2 (contactin-associated protein-2) eller LGI1 (leucine-rich, glioma inactivated protein 1) och komplettering med separat analys av dessa specificiteter rekommenderas.
I serum, relevansen av antikroppar med nivåer under 300 pmol/L är tveksam. Vid autoimmun encefalit är antikroppsnivån i serum ofta över 300-500 pmol/L.
Senast uppdaterat: 2025-12-05