INDIVIDUAL TEST 837
Alpha-Enolase Antibodies
Indication
Suspicion of paraneoplastic retinopathy (Carcinoma Associated Retinopathy, CAR)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Western blot
Reference interval
Negative
Result
Results are reported as negative or positive.
Interpretation
Alpha-enolase antibodies are detected in paraneoplastic retinopathy (Carcinoma Associated Retinopathy, CAR) which is associated with melanoma.
These autoantibodies are believed to inhibit the catalytic function of alpha-enolase and increase intracellular ATP, resulting in the destruction of retinal neurons.
References
- Adamus G et al. Clin Immunol. 2020. Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy. PMID: 31770612
- Kang L, Wan C. J Neurol. 2022. Paraneoplastic syndrome in neuroophthalmology. PMID: 35779086
Last updated: 2025-11-25
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ENSKILD ANALYS 837
alfa-Enolase-antikroppar
Indikation
Misstanke om paraneoplastisk retinopati (carcinoma associated retinopathy, CAR)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Western blot
Referensintervall
Negativt
Resultat
Resultat anges som negativt eller positivt.
Tolkning
Alfa-enolase antikroppar kan detekteras vid paraneoplastisk retinopati (carcinoma associated retinopathy, CAR) som är associerat med melanom.
Dessa autoantikroppar tros inhibera den katalytiska funktionen hos alfa-enolase och öka intracellulärt ATP med destruktion av retinala neuron som följd.
Referenser
- Adamus G et al. Clin Immunol. 2020. Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy. PMID: 31770612
- Kang L, Wan C. J Neurol. 2022. Paraneoplastic syndrome in neuroophthalmology. PMID: 35779086
Senast uppdaterat: 2025-11-25