INDIVIDUAL TEST 837
Alpha-Enolase Antibodies
Indication
Suspicion of paraneoplastic retinopathy (Carcinoma Associated retinopathy CAR).
Method
Immunoblot
Result
The result is expressed as negative or positive.
Interpretation
Alpha-enolase antibodies occur almost exclusively in paraneoplastic retinopathy (Carcinoma Associated retinopathy CAR). The associated neoplasm is melanoma. These autoantibodies are believed to provide increased intracellular calcium due to autoantibody-induced apoptosis, which may lead to the degeneration of photoreceptors in the retina. Autoantibodies are believed to inhibit the catalytic function of alpha-enolase, causing reduction of ATP and a consequent increase in intracellular ATP, which in turn causes changes in the glycolysis of retinal neurons and destruction of these.
References
- Magrys et al. J Clin Immunol. 2007 PMID: 17235687
Last updated: 2024-06-26
Can't find what you're looking for? We are here to help
ENSKILD ANALYS 837
alfa-Enolase-antikroppar
Indikation
Misstanke om paraneoplastisk retinopati (carcinoma associated retinopathy CAR).
Metod
Immunoblot
Resultat
Resultatet anges som negativt eller positivt.
Tolkning
Alfa-enolase-antikroppar förekommer i princip uteslutande vid paraneoplastisk retinopati (carcinoma associated retinopathy CAR). Associerad neoplasm är melanom. Dessa autoantikroppar anses ge ökat intracellulärt kalcium pga autoantikropps inducerad apoptos, vilket kan leda till degenerering av fotoreceptorer i retina. Autoantikroppar tros inhibera den katalytiska funktionen hos alfa-enolase vilket orsakar minskning av ATP och därmed en ökning av intracellulärt ATP vilket i sin tur orsakar förändringar i glykolysen hos retinala neuron och destruktion av dessa.
Referenser
- Magrys et al. J Clin Immunol. 2007 PMID: 17235687
Senast uppdaterat: 2024-06-26