INDIVIDUAL TEST 838
Glycine Receptor Antibodies (IgG)
Indication
Suspicion of Stiff person syndrome and especially PERM (Progressive encephalomyelitis with rigidity and myoclonus).
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
Serum: <1:10 negative
CSF: negative
Result
Results are reported as negative or positive. A positive result is followed by a titer (serum).
Interpretation
GlyR mediates the post-synaptic inhibition in the central nervous system. GlyR antibodies are primarily associated with PERM (progressive encephalomyelitis with rigidity and myoclonus) variant of stiff person syndrome. In less than 10% of cases, anti-GlyR antibodies are associated with underlying malignancy.
References
- Alexopoulos H, Dalakas MC. J Autoimmun. 2019. The immunobiology of autoimmune encephalitides. PMID: 31611142
- Graus F, et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Guasp M et al. Neurol Neuroimmunol Neuroinflamm. 2025. Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor Antibodies: Clinical Features and Outcomes. PMID: 40953327
- Winklehner M et al. Neurol Neuroimmunol Neuroinflamm. 2024. Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor and GAD65 Antibodies: Case Report and Potential Mechanisms. PMID: 39213470
- Cullinane PW et al. Handb Clin Neurol. 2024. Stiff person syndrome. PMID: 39174250
- Chia NH et al. Ann Clin Transl Neurol. 2023. Stiff person spectrum disorder diagnosis, misdiagnosis, and suggested diagnostic criteria. PMID: 37212351
Last updated: 2025-11-25
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ENSKILD ANALYS 838
Glycinreceptor-antikroppar (IgG)
Indikation
Misstanke om Stiff person syndrom och framför allt PERM (Progressiv encefalomyelit med rigiditet och myoklonier)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
Serum: <1:10 negativt
Likvor: negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras (serum).
Tolkning
GlyR medierar postsynaptisk inhibering i det centrala nervsystemet. GlyR antikroppar är associerade med varianten PERM (progressiv encefalomyelit med rigiditet och myoklonier) vid stiff person syndrome. I mindre än 10% av fallen är anti-GlyR antikroppar associerade med underliggande malignitet.
Referenser
- Alexopoulos H, Dalakas MC. J Autoimmun. 2019. The immunobiology of autoimmune encephalitides. PMID: 31611142
- Graus F, et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Guasp M et al. Neurol Neuroimmunol Neuroinflamm. 2025. Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor Antibodies: Clinical Features and Outcomes. PMID: 40953327
- Winklehner M et al. Neurol Neuroimmunol Neuroinflamm. 2024. Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor and GAD65 Antibodies: Case Report and Potential Mechanisms. PMID: 39213470
- Cullinane PW et al. Handb Clin Neurol. 2024. Stiff person syndrome. PMID: 39174250
- Chia NH et al. Ann Clin Transl Neurol. 2023. Stiff person spectrum disorder diagnosis, misdiagnosis, and suggested diagnostic criteria. PMID: 37212351
Senast uppdaterat: 2025-11-25