DIAGNOSTIC TEST 845

VGCC Antibodies

Diagnostic test for antibodies against VGCC. For suspicion of paraneoplastic neuropathy, Lambert-Eaton myasthenic syndrome and cerebellar dysfunction.

Indication

Suspicion of paraneoplastic neuropathy, Lambert-Eaton myasthenic syndrome, and cerebellar dysfunction

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Radioimmunoprecipitation (RIP)

Reference interval

VGCC N type <110 pmol/L negative

VGCC P/Q type <40 pmol/L negative

Result

Results are reported as negative or positive with a value.

Interpretation

Voltage gated calcium channel (VGCC) P/Q-type antibodies are associated with Lambert Eaton’s myasthenic syndrome but can also occur in paraneoplastic neuropathy (e.g. small cell lung cancer) and cerebellar dysfunction. Antibody titers can be used to monitor treatment effect.

In contrast to antibodies against VGCC P/Q-type, the clinical importance of antibodies against VGCC N-type alone seems to be less understood.

References

  • Dalmau J et al. Physiol Rev. 2017. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. PMID: 28298428
  • Alexopoulos H, Dalakas MC. J Autoimmun. 2019. The immunobiology of autoimmune encephalitides. PMID: 31611142
  • Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622

Included in these panels

Need pricing information?

Get a quote

How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. If you are a new customer, please also include a completed customer information form.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Last updated: 2026-09-21