INDIVIDUAL TEST 851
DPPX Antibodies (IgG)
Indication
Suspicion of autoimmune encephalitis
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
Within Sweden
- room temperature
International
- cold
Method
Cell-based assay (CBA), Indirect immunofluorescence (IIF)
Reference interval
Serum
- <1:10 negative
CSF
- negative
Result
Results are reported as negative or positive. A positive result is followed by a titer (serum).
Interpretation
Analysis for anti-neuronal antibodies against DPPX in patient serum or CSF is of particular importance in differential diagnosis of encephalitis. DPPX, which is mainly produced in brain tissue, interacts with the KV4 potassium channel. DPPX is an important regulator of membrane viability in hippocampus CA1 pyramid cells. Antibodies against DPPX can lead to autoimmune encephalitis.
Antibodies against DPPX are graded as Lower-risk antibodies with a frequency of <10% of underlying cancer and a positive result yields 0 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
References
- Leypoldt F et al. Ann N Y Acad Sci. 2015. Autoimmune encephalopathies. PMID: 25315420
- Dalmau J et al. Physiol Rev. 2017. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. PMID: 28298428
- Dalmau J et al. Lancet Neurol. 2019. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. PMID: 31326280
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Flanagan EP et al. JAMA Neurol. 2023. Autoimmune Encephalitis Misdiagnosis in Adults. PMID: 36441519
Last updated: 2024-08-13
Can't find what you're looking for? We are here to help
ENSKILD ANALYS 851
DPPX-antikroppar (IgG)
Indikation
Misstanke om autoimmun ecefalit
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- li>
Minim. volym: 0,5 mL
Transport
Inom Sverige
- rumstemperatur
Internationellt
- kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
Serum
- <1:10 negativt
Likvor
- negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras (serum).
Tolkning
Analys av anti-neuronala antikroppar mot DPPX i patientserum eller likvor är av intresse vid differentialdiagnos av encefalit. DPPX som huvudsakligen produceras i hjärnvävnad, interagerar med kaliumkanalen KV4. DPPX är en viktig reglerare av membranens retbarhet i hippocampus CA1 pyramidceller. Antikroppar mot DPPX kan leda till autoimmun encefalit.
Antikroppar riktade mot DPPX bedöms vara Lower-risk antibodies med en förekomst på <10% för en underliggande cancer och positivitet ger 0 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
Referenser
- Leypoldt F et al. Ann N Y Acad Sci. 2015. Autoimmune encephalopathies. PMID: 25315420
- Dalmau J et al. Physiol Rev. 2017. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. PMID: 28298428
- Dalmau J et al. Lancet Neurol. 2019. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. PMID: 31326280
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622 Flanagan EP et al. JAMA Neurol. 2023. Autoimmune Encephalitis Misdiagnosis in Adults. PMID: 36441519
Senast uppdaterat: 2024-08-13