INDIVIDUAL TEST 851

DPPX (dipeptidyl aminopeptidase-like protein 6) antibodies

IndicationSuspicion of autoimmune encephalitis.MethodIndirect immunofluorescence (IIF) using transfected cells.ResponseThe result is reported as positive or negative. A positive result is followed by a titer (serum).InterpretationAnalysis for anti-neuronal antibodies against DPPX (dipeptidyl aminopeptidase-like protein 6) in patient serum or CSF are of particular importance in differential diagnosis of encephalitis. DPPX, which is mainly produced in brain tissue, interacts with the KV4 potassium channel. DPPX is an important regulator of membrane viability in hippocampus CA1 pyramid cells. Antibodies against DPPX can lead to autoimmune encephalitis.

DPPX belongs to the group of extracellular antigens. Generally, immunotherapy is more often effective in autoantibodies directed against extracellular antigens than in autoantibodies against intracellular antigens..

ReferencesBoronat A, Gelfand JM, Gresa-Arribas N, Jeong HY, Walsh M, Roberts K, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R, Graus F, Rudy B, Dalmau J. Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels. Ann Neurol 73 (2013) 120-128. PMID:23225603

Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology 77 (2011) 179-189. PMID: 21747075

Frank Leypoldt, et.al.  “Autoimmune encephalopathies”  Ann. N.Y. Acad. Sci. (2014) 1–21. PMID 25315420

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Neurology

ENSKILD ANALYS 851

DPPX (dipeptidylaminopeptidas liknande protein 6) antikroppar

IndikationMisstanke om autoimmun encefalit.MetodIndirekt immunofluorescens (IIF) med transfekterade celler.SvarResultatet anges som positiv eller negativ. Positivt resultat titreras (serum).TolkningAnalys av anti-neuronala antikroppar mot DPPX (dipeptidylaminopeptidas liknande protein 6) i patientserum eller likvor är av intresse vid differentialdiagnos av encefalit. DPPX som huvudsakligen produceras i hjärnvävnad, interagerar med kaliumkanalen KV4. DPPX är en viktig reglerare av membranens retbarhet i hippocampus CA1 pyramidceller. Antikroppar mot DPPX kan leda till autoimmun encefalit.

DPPX räknas till gruppen extracellulära antigen. Generellt sett är behandling med immunoterapi oftare effektiv vid autoantikroppar riktade mot extracellulära antigen än vid autoantikroppar mot intracellulära antigen.

ReferenserBoronat A, Gelfand JM, Gresa-Arribas N, Jeong HY, Walsh M, Roberts K, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R, Graus F, Rudy B, Dalmau J. Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels. Ann Neurol 73 (2013) 120-128. PMID:23225603

Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology 77 (2011) 179-189. PMID: 21747075

Frank Leypoldt, et.al. “Autoimmune encephalopathies” Ann. N.Y. Acad. Sci. (2014) 1–21. PMID 25315420

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