INDIVIDUAL TEST 852
IgLON5 Antibodies (IgG)
Indication
In case of suspected autoimmune encephalitis
Method
Indirect immunofluorescence (IIF)
Result
The result is expressed as negative or positive with titer.
Interpretation
The IgLON5 protein is a neuronal cell surface adhesion molecule with unknown function. Antibodies against IgLON5 has been found in a few cases in patients with encephalitis and neurodegeneration with abnormal sleep movements and behavior and obstructive sleep apnea. Other present neurological symptoms are gait instability, dysarthria, dysphagia, ataxia or chorea.
The antigen has been defined as an extracellular antigen.
Generally, treatment with immunotherapy is more effective against auto-antibodies directed to extracellular antigens than with auto-antibodies against intracellular antigens.
References
- Sabater L et. al. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. Lancet Neurol. 2014 Jun;13(6):575-86. PMID: 24703753
- Leypoldt F, Armangue T, Dalmau J. Autoimmune encephalopathies. Ann N Y Acad Sci. 2014 Oct 14. PMID: 25315420
Last updated: 2024-06-19
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ENSKILD ANALYS 852
IgLON5-antikroppar (IgG)
Indikation
Misstanke om autoimmun encefalit
Metod
Indirekt immunofluorescens (IIF)
Resultat
Resultatet anges som negativt eller positivt med titer.
Tolkning
IgLON5 är ett neuronalt cellyteprotein med okänd function. Antikropppar mot IgLON5 har detekterats i ett fåtal fall hos patienter med encefalit och neurodegeneration, med avvikande sovmönster samt obstruktiv sömnapné. Andra närvarande neurologiska symptom i dessa patientfall; avvikande gångmönster, dysartri, dysfagi, ataxi eller chorea.
Antigenet har definierats som ett extracellulärt antigen.
Generellt är behandling med immunterapi effektivare mot autoantikroppar riktade mot extracellulära antigener än med autoantikroppar mot intracellulära antigener.
Referenser
- Sabater L et. al. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. Lancet Neurol. 2014 Jun;13(6):575-86. PMID: 24703753
- Leypoldt F, Armangue T, Dalmau J. Autoimmune encephalopathies. Ann N Y Acad Sci. 2014 Oct 14. PMID: 25315420
Senast uppdaterat: 2024-06-19