DIAGNOSTIC TEST 852

IgLON5 Antibodies  (IgG)

Diagnostic test for antibodies against IgLON5. For suspicion of autoimmune encephalitis.

Indication

Suspicion of autoimmune encephalitis

Sample material

Serum

  • Minim. volume: 0,5 mL

CSF

  • Minim. volume: 0,5 mL

Transport

  • Within Sweden: room temperature
  • International: cold

Method

Cell-based assay (CBA), indirect immunofluorescence (IIF)

Reference interval

Serum: <1:10 negative

CSF: negative

Result

Results are reported as negative or positive. A positive result is followed by a titer (serum).

Interpretation

Anti-IgLON5 antibodies are associated with chronic progressive autoimmune encephalopathy. The clinical picture is complex and includes unstable gait, parkinsonism, dystonia, bulbar symptoms and dementia-like cognitive impairment. A sleep disorder with obstructive sleep apnea is also often seen. The haplotype HLA-DRB1*10:01/DQB1*05:01 is strongly associated with the condition.

References

  • Graus F, Sabater L, Gaig C, Gelpi E, Iranzo A, Dalmau JO, Santamaria J. Anti-IgLON5 Disease 10 Years Later: What We Know and What We Do Not Know. Neurol Neuroimmunol Neuroinflamm. 2025;12(1)
  • Gaig C, Sabater L. Clinical presentations and antibody mechanisms in anti-IgLON5 disease. Rev Neurol. 2024;180(9):940–949
  • Gelpi E, Höftberger R, Compta Y, et al. Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy. Acta Neuropathol. 2024; 148:53.
  • Madetko N, Marzec W, Kowalska A, et al. Anti-IgLON5 Disease – The Current State of Knowledge and Further Perspectives. Front Immunol. 2022.

Included in these panels

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How to order

This test is available worldwide for hospitals, clinics, and physicians.

  1. Print and complete the request form

    Download the request form. Clearly state the name and phone number of the referring hospital, clinic, or physician. If you are a new customer, please also include a completed customer information form.

  2. Prepare your samples

    Serum: At least 0.5 mL serum (plain serum tubes without additives).
    CSF: At least 0.5 mL CSF (polypropylene tubes).

  3. Send samples and request form

    Within Sweden
    Samples can be sent at room temperature to:
    Envelopes and smaller boxes:
    Wieslab AB, Box 50117, 20211 Malmö, Sweden

    Larger boxes and frozen samples:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

    International
    Send samples cold to:
    Wieslab AB, Lundavägen 151, 21224 Malmö, Sweden

Last updated: 2026-04-30