INDIVIDUAL TEST 852

IgLON5 antibodies

IndicationIn case of suspected autoimmune encephalitisMethodIndirect immunofluorescence (IIF)ResultThe result is expressed as negative or positive with titer.InterpretationThe IgLON5 protein is a neuronal cell surface adhesion molecule with unknown function. Antibodies against IgLON5 has been found in a few cases in patients with encephalitis and neurodegeneration with abnormal sleep movements and behavior and obstructive sleep apnea.  Other present neurological symptoms are gait instability, dysarthria, dysphagia, ataxia or chorea.

The antigen has been defined as an extracellular antigen.

Generally, treatment with immunotherapy is more effective against auto-antibodies directed to extracellular antigens than with auto-antibodies against intracellular antigens.

ReferencesSabater L et. al. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. Lancet Neurol. 2014 Jun;13(6):575-86. PMID: 24703753

Leypoldt F, Armangue T, Dalmau J. Autoimmune encephalopathies. Ann N Y Acad Sci. 2014 Oct 14. PMID: 25315420

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Neurology

ENSKILD ANALYS 852

IgLON5 antikroppar

IndikationMisstanke om autoimmun encefalitMetodIndirekt immunofluorescens (IIF)ResultatResultatet anges som negativt eller positivt med titer.TolkningIgLON5 är ett neuronalt cellyteprotein med okänd function. Antikropppar mot IgLON5 har detekterats i ett fåtal fall hos patienter med encefalit och neurodegeneration, med avvikande sovmönster samt obstruktiv sömnapné. Andra närvarande neurologiska symptom i dessa patientfall; avvikande gångmönster, dysartri, dysfagi, ataxi eller chorea.

Antigenet har definierats som ett extracellulärt antigen.

Generellt är behandling med immunterapi effektivare mot autoantikroppar riktade mot extracellulära antigener än med autoantikroppar mot intracellulära antigener.

ReferenserSabater L et. al. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. Lancet Neurol. 2014 Jun;13(6):575-86. PMID: 24703753

Leypoldt F, Armangue T, Dalmau J. Autoimmune encephalopathies. Ann N Y Acad Sci. 2014 Oct 14. PMID: 25315420

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