INDIVIDUAL TEST 854
CARP VIII Antibodies (IgG)
Indication
Suspicion of paraneoplastic cerebellar degeneration (PCD) associated with malignant melanoma
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
Serum: <1:10 negative
CSF: negative
Result
Results are reported as negative or positive. A positive result is followed by a titer (serum).
Interpretation
Autoantibodies against CARP VIII are associated with malignant melanoma with paraneoplastic cerebellar degeneration (PCD).
References
- Jarius S, Wildemann B. J Neuroinflammation. 2015. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. PMID: 26377085
- Kerstens J et al. Neurol Neuroimmunol Neuroinflamm. 2024. Autoimmune Encephalitis and Paraneoplastic Neurologic Syndromes: A Nationwide Study on Epidemiology and Antibody Testing Performance. PMID: 39467237
Last updated: 2025-11-25
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ENSKILD ANALYS 854
CARP VIII-antikroppar (IgG)
Indikation
Misstanke om paraneoplastisk cerebellär degeneration (PCD) med malignt melanom
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
Serum: <1:10 negativt
Likvor: negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras (serum).
Tolkning
Autoantikroppar mot CARP VIII har rapporterats vid malignt melanom med paraneoplastisk cerebellär degeneration (PCD).
Referenser
- Jarius S, Wildemann B. J Neuroinflammation. 2015. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. PMID: 26377085
- Kerstens J et al. Neurol Neuroimmunol Neuroinflamm. 2024. Autoimmune Encephalitis and Paraneoplastic Neurologic Syndromes: A Nationwide Study on Epidemiology and Antibody Testing Performance. PMID: 39467237
Senast uppdaterat: 2025-11-25