INDIVIDUAL TEST 855
HOMER3 Antibodies (IgG)
Indication
In case of suspected autoimmune encephalitis/autoimmune cerebellar ataxia.
Method
Indirect immunofluorescence (IIF)
Result
Results are reported as negative or positive. Positive results are reported with a titer.
Interpretation
The presence of autoantibodies to protein Homer-3 has been reported in cases of autoimmune cerebellar ataxia.
Homer proteins are a family of scaffolding proteins of the postsynaptic density. Homer-3 co-localizes modulates the activity of group I metabotropic glutamate receptors (mGluR1 and mGluR5).
The presence of Homer-3 autoantibodies should be considered in the differential diagnosis of patients with subacute cerebellar ataxia of unknown cause.
References
- Höftberger R et.al. Patient with homer-3 antibodies and cerebellitis, JAMA Neurol. 2013 Apr;70(4):506-9. PMID: 23400636
Last updated: 2024-06-19
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ENSKILD ANALYS 855
HOMER3-antikroppar (IgG)
Indikation
Misstanke om autoimmun encefalit / autoimmun cerebellär ataxi.
Metod
Indirekt immunofluorescens (IIF)
Resultat
Resultaten rapporteras som negativa eller positiva. Positiva resultat redovisas med en titer.
Tolkning
Förekomst av autoantikroppar mot proteinet Homer-3 har rapporterats i fall av autoimmun cerebellär ataxi.Homer proteiner är en familj av scaffolding proteiner i den postsynaptiska densiteten. Homer-3 co-lokaliserar och modulerar aktiviteten av grupp I metabotropiska glutamatreceptorer (mGluR1 och mGluR5).
Närvaron av Homer-3 autoantikroppar bör övervägas i differentialdiagnos av patienter med subakut cerebellär ataxi med okänd orsak.
Referenser
- Höftberger R et.al. Patient with homer-3 antibodies and cerebellitis, JAMA Neurol. 2013 Apr;70(4):506-9. PMID: 23400636
Senast uppdaterat: 2024-06-19