INDIVIDUAL TEST 856

ITPR1 antibodies

IndicationIn case of suspected autoimmune encephalitis /autoimmune cerebellar ataxia.MethodIndirect immunofluorescence (IIF)ResponseResults are reported as negative or positive. Positive results are reported with a titer.InterpretationPresence of autoantibodies to the protein inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) have been reported in cases of autoimmune cerebellar ataxia.

The inositol 1,4,5-trisphosphate receptors are localized to intracellular membranes, such as the endoplasmic reticulum. Inositol 1,4,5-trisphosphate receptors play an important role in intracellular Ca2 + signaling in a variety of cell types.

The presence of ITPR1 autoantibodies should be considered in the differential diagnosis of patients with subacute cerebellar ataxia of unknown cause.

The antigen has been defined as an intracellular antigen.

Generally, treatment with immunotherapy is more effective against auto-antibodies directed to extracellular antigens than with auto-antibodies against intracellular antigens.

ReferencesSven Jarius, et.al., Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia, Journal of Neuroinflammation, 2014, 11:206. PMID: 25498830

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Neurology

ENSKILD ANALYS 856

ITPR1 antikroppar

IndikationMisstanke om autoimmun encefalit/autoimmun cerebellär ataxi.MetodIndirekt immunofluorescens (IIF)SvarResultaten rapporteras som negativa eller positiva. Positiva resultat redovisas med en titer.TolkningFörekomst av autoantikroppar mot proteinet inositol 1,4,5-trifosfat receptor typ 1 (ITPR1) har rapporterats i fall av autoimmun cerebellär ataxi.

Inositol 1,4,5-trifosfat receptorer är lokaliserade till intracellulära membran, såsom det endoplasmatiska retiklet. Inositol 1,4,5-trifosfat receptorer spelar en viktig roll i intracellulär Ca2 + signalering i en mängd olika celltyper.

Förekomsten av ITPR1 autoantikroppar bör övervägas i differentialdiagnos av patienter med subakut cerebellär ataxi av okänd orsak.

Antigenet har definierats som ett intracellulärt antigen.

Generellt är behandling med immunterapi effektivare mot autoantikroppar riktade mot extracellulära antigener än med autoantikroppar mot intracellulära antigener.

ReferenserSven Jarius, et.al., Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia, Journal of Neuroinflammation, 2014, 11:206. PMID: 25498830

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