INDIVIDUAL TEST 856
ITPR1 Antibodies (IgG)
Indication
Suspicion of autoimmune encephalitis or autoimmune cerebellar ataxia
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
Serum: <1:100 negative
CSF: negative
Result
Results are reported as negative or positive. A positive result is followed by a titer (serum).
Interpretation
Autoantibodies against ITPR1 are reported in autoimmune cerebellar ataxia and sub-acute neuropathy, other neurological manifestations can occur. Association with malignancy has been reported.
References
- Cirkel A et al. Neurol Res Pract. 2021. Paraneoplastic encephalomyeloradiculits with multiple autoantibodies against ITPR-1, GFAP and MOG: case report and literature review. PMID: 34635185
- Jarius S et al. J Neuroinflammation. 2022. Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature. PMID: 35907972
Last updated: 2025-12-01
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ENSKILD ANALYS 856
ITPR1-antikroppar (IgG)
Indikation
Misstanke om autoimmun encefalit eller autoimmun cerebellär ataxi
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
Serum: <1:100 negativt
Likvor: negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras (serum).
Tolkning
Autoantikroppar mot ITPR1 har rapporterats vid autoimmun cerebellär ataxi och subakut neuropati, även andra neurologiska manifestationer. Förekomst av antikroppar har associerats med malignitet.
Referenser
- Cirkel A et al. Neurol Res Pract. 2021. Paraneoplastic encephalomyeloradiculits with multiple autoantibodies against ITPR-1, GFAP and MOG: case report and literature review. PMID: 34635185
- Jarius S et al. J Neuroinflammation. 2022. Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature. PMID: 35907972
Senast uppdaterat: 2025-12-01