INDIVIDUAL TEST 871

Neuronal autoantibodies

IndicationAutoimmune cerebellar ataxia

MethodIndirect immunofluorescence. The method is not yet validated.

AnswerReported as negative or positive with titer.
Can be tested in serum and CSF.

InterpretationAntibodies against Neurochondrin have been reported in cases with autoimmune cerebellar degeneration with rapidly progressive cerebellar ataxia. The antibodies are usually not associated with malignancy.

References1. Miske R, et al. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration. Neurol Neuroimmunol Neuroinflamm. 2016 Dec 5;4(1):e307. PMID: 27957508
2. Shelly S, et al. Neurochondrin neurological autoimmunity. Neurol Neuroimmunol Neuroinflamm. 2019 Sep 11;6(6):e612. PMID: 31511329

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ENSKILD ANALYS 871

Neuronala autoantikroppar

IndikationAutoimmun cerebellär ataxi

MetodIndirekt immunofluorescens. Metoden är ännu inte validerad.

SvarAnges som negativ eller positiv med titer.
Kan testas i serum och likvor.

TolkningAntikroppar mot neurochondrin har rapporterats vid autoimmun cerebellär degeneration med snabbt progredierande ataxi. De är vanligtvis inte associerade med malignitet.

Referenser1. Miske R, et al. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration. Neurol Neuroimmunol Neuroinflamm. 2016 Dec 5;4(1):e307. PMID: 27957508
2. Shelly S, et al. Neurochondrin neurological autoimmunity. Neurol Neuroimmunol Neuroinflamm. 2019 Sep 11;6(6):e612. PMID: 31511329

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