INDIVIDUAL TEST 871
Neurochondrin Antibodies (IgG)
Indication
Suspicion of autoimmune cerebellar ataxia
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
Serum: <1:100 negative
CSF: negative
Result
Results are reported as negative or positive. A positive result is followed by a titer (serum).
Interpretation
Antibodies against neurochondrin have been reported in cases with autoimmune cerebellar degeneration with rapidly progressive cerebellar ataxia. They are usually not associated with malignancy.
References
- Ahmad R et al. Front Immunol. 2024. Case report: Refractory focal motor seizure associated with cerebrospinal fluid neurochondrin antibody. PMID: 39376559
- Schwarzwald A et al. Eur J Neurol. 2023. Anti-neurochondrin antibody as a biomarker in primary autoimmune cerebellar ataxia-a case report and review of the literature. PMID: 36437687
- Schwarzwald A et al. Eur J Neurol. 2023. Anti-neurochondrin antibody as a biomarker in primary autoimmune cerebellar ataxia-a case report and review of the literature. PMID: 36437687
Last updated: 2025-12-05
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ENSKILD ANALYS 871
Neurochondrin-antikroppar (IgG)
Indikation
Misstanke om autoimmun cerebellär ataxi
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
Serum: <1:100 negativt
Likvor: negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras (serum).
Tolkning
Antikroppar mot neurochondrin har rapporterats vid autoimmun cerebellär degeneration med snabbt progredierande ataxi. De är vanligtvis inte associerade med malignitet.
Referenser
- Ahmad R et al. Front Immunol. 2024. Case report: Refractory focal motor seizure associated with cerebrospinal fluid neurochondrin antibody. PMID: 39376559
- Schwarzwald A et al. Eur J Neurol. 2023. Anti-neurochondrin antibody as a biomarker in primary autoimmune cerebellar ataxia-a case report and review of the literature. PMID: 36437687
- Schwarzwald A et al. Eur J Neurol. 2023. Anti-neurochondrin antibody as a biomarker in primary autoimmune cerebellar ataxia-a case report and review of the literature. PMID: 36437687
Senast uppdaterat: 2025-12-05