INDIVIDUAL TEST 872
Neurexin-3 Alpha Antibodies (IgG)
Indication
Suspicion of autoimmune encephalitis.
Method
Indirect immunofluorescence. The method is not yet validated.
Result
Reported as negative or positive with titer.
Can be tested in serum and CSF.
Interpretation
Autoantibodies against Neurexin-3 alpha have been reported in a few cases of autoimmune encephalitis. Typical clinical features are similar to NMDAR-encephalitis but with less prominent psychiatric symptoms.
References
- Gresa-Arribas N et al. Human neurexin-3a antibodies associate with encephalitis and alter synapse development. American Academy of Neurology 2016 June 14, 2016; 86 (24)
- Dalmau J et al. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr; 97(2): 839–887. PMID: 28298428
- Pollak TA, Lennox BR, Müller S et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. Lancet Psychiatry 2020;7(1):93‐108. PMID: 31669058.
Last updated: 2024-06-18
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ENSKILD ANALYS 872
Neurexin-3 alpha-antikroppar (IgG)
Indikation
Misstanke om autoimmun encefalit.
Metod
Indirekt immunofluorescens. Metoden är ännu inte validerad.
Resultat
Anges som negativ eller positiv med titer. Kan testas i serum och likvor.
Tolkning
Autoantikroppar mot Neurexin-3 alpha har rapporterats i ett fåtal fall av autoimmun encefalit. Den kliniska bilden beskrivs likna NMDAR-encefalit men psykiska symptom kan vara mindre uttalade.
Referenser
- Gresa-Arribas N et al. Human neurexin-3a antibodies associate with encephalitis and alter synapse development. American Academy of Neurology 2016 June 14, 2016; 86 (24)
- Dalmau J et al. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr; 97(2): 839–887. PMID: 28298428
- Pollak TA, Lennox BR, Müller S et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. Lancet Psychiatry 2020;7(1):93‐108. PMID: 31669058
Senast uppdaterat: 2024-06-18