INDIVIDUAL TEST 872
Neurexin-3 Alpha Antibodies (IgG)
Indication
Suspicion of autoimmune encephalitis
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
Serum: <1:100 negative
CSF: negative
Result
Results are reported as negative or positive. A positive result is followed by a titer (serum).
Interpretation
Autoantibodies against Neurexin-3 alpha have been reported in a few cases of autoimmune encephalitis. Typical clinical features are similar to NMDAR-encephalitis but with less prominent psychiatric symptoms.
References
- Dalmau J et al. Physiol Rev. 2017. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. PMID: 28298428
- Pollak TA et al. Lancet Psychiatry 2020. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. PMID: 31669058
- Ancona C et al. Front Pediatr. 2022. Autoimmune Encephalitis and Other Neurological Syndromes With Rare Neuronal Surface Antibodies in Children: A Systematic Literature Review. PMID: 35515348
- Hansen N et al. Brain Sci. 2021. Mild Amnestic Cognitive Impairment and Depressive Symptoms in Autoimmune Encephalitis Associated with Serum Anti-Neurexin-3α Autoantibodies. PMID: 34064006
Last updated: 2025-10-09
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ENSKILD ANALYS 872
Neurexin-3 alpha-antikroppar (IgG)
Indikation
Misstanke om autoimmun encefalit
Provmaterial
Serum
- Minim. volym: 0,5 mL
- Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
Serum: <1:100 negativt
Likvor: negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras (serum).
Tolkning
Autoantikroppar mot Neurexin-3 alpha har rapporterats i ett fåtal fall av autoimmun encefalit. Den kliniska bilden beskrivs likna NMDAR-encefalit men psykiska symptom kan vara mindre uttalade.
Referenser
- Dalmau J et al. Physiol Rev. 2017. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. PMID: 28298428
- Pollak TA et al. Lancet Psychiatry 2020. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. PMID: 31669058
- Ancona C et al. Front Pediatr. 2022. Autoimmune Encephalitis and Other Neurological Syndromes With Rare Neuronal Surface Antibodies in Children: A Systematic Literature Review. PMID: 35515348
- Hansen N et al. Brain Sci. 2021. Mild Amnestic Cognitive Impairment and Depressive Symptoms in Autoimmune Encephalitis Associated with Serum Anti-Neurexin-3α Autoantibodies. PMID: 34064006
Senast uppdaterat: 2025-10-09