INDIVIDUAL TEST 872

Neurexin-3 alpha antibodies

Indication

Suspicion of autoimmune encephalitis. 

Method 

Indirect immunofluorescence. The method is not yet validated. 

Response

Reported as negative or positive with titer. 

Can be tested in serum and CSF. 

Interpretation

Autoantibodies against Neurexin-3 alpha have been reported in a few cases of autoimmune encephalitis. Typical clinical features are similar to NMDAR-encephalitis but with less prominent psychiatric symptoms. 

Referenser

  1. Gresa-Arribas N et al. Human neurexin-3a antibodies associate with encephalitis and alter synapse development. American Academy of Neurology 2016 June 14, 2016; 86 (24)  

  2. Dalmau J et al. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr; 97(2): 839–887. PMID: 28298428 

  3. Pollak TA, Lennox BR, Müller S et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune originLancet Psychiatry 2020;7(1):93108. PMID: 31669058. 

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Neurology

ENSKILD ANALYS 872

Neurexin-3 alpha antikroppar

Indikation Misstanke om autoimmun encefalit. 

Metod Indirekt immunofluorescens. Metoden är ännu inte validerad. 

Svar Anges som negativ eller positiv med titer.
Kan testas i serum och likvor.

TolkningAutoantikroppar mot Neurexin-3 alpha har rapporterats i ett fåtal fall av autoimmun encefalit. Den kliniska bilden beskrivs likna NMDAR-encefalit men psykiska symptom kan vara mindre uttalade. 

Referenser

  1. Gresa-Arribas N et al. Human neurexin-3a antibodies associate with encephalitis and alter synapse development. American Academy of Neurology 2016 June 14, 2016; 86 (24)  

  2. Dalmau J et al. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr; 97(2): 839–887. PMID: 28298428 

  3. Pollak TA, Lennox BR, Müller S et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune originLancet Psychiatry 2020;7(1):93108. PMID: 31669058

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