Vial

INDIVIDUAL TEST 872

Neurexin-3 Alpha Antibodies (IgG)

Indication

Suspicion of autoimmune encephalitis. 

Method 

Indirect immunofluorescence. The method is not yet validated. 

Response

Reported as negative or positive with titer. 

Can be tested in serum and CSF. 

Interpretation

Autoantibodies against Neurexin-3 alpha have been reported in a few cases of autoimmune encephalitis. Typical clinical features are similar to NMDAR-encephalitis but with less prominent psychiatric symptoms. 

Referenser

  1. Gresa-Arribas N et al. Human neurexin-3a antibodies associate with encephalitis and alter synapse development. American Academy of Neurology 2016 June 14, 2016; 86 (24)  

  2. Dalmau J et al. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr; 97(2): 839–887. PMID: 28298428 

  3. Pollak TA, Lennox BR, Müller S et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune originLancet Psychiatry 2020;7(1):93108. PMID: 31669058. 

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Vial

ENSKILD ANALYS 872

Neurexin-3 alpha-antikroppar (IgG)

Indikation

Misstanke om autoimmun encefalit. 

Metod

Indirekt immunofluorescens. Metoden är ännu inte validerad. 

Svar

Anges som negativ eller positiv med titer.
Kan testas i serum och likvor.

Tolkning

Autoantikroppar mot Neurexin-3 alpha har rapporterats i ett fåtal fall av autoimmun encefalit. Den kliniska bilden beskrivs likna NMDAR-encefalit men psykiska symptom kan vara mindre uttalade. 

Referenser

  1. Gresa-Arribas N et al. Human neurexin-3a antibodies associate with encephalitis and alter synapse development. American Academy of Neurology 2016 June 14, 2016; 86 (24)  

  2. Dalmau J et al. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr; 97(2): 839–887. PMID: 28298428 

  3. Pollak TA, Lennox BR, Müller S et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune originLancet Psychiatry 2020;7(1):93108. PMID: 31669058

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