Vial

INDIVIDUAL TEST 876

GABA-A receptor antibodies

Indication Suspicion of autoimmune encephalitis.  

Method Indirect immunofluorescence. The method is not yet validated for clinical laboratory routine diagnostics. 

Result Reported as negative or positive with titer.  

Interpretation Autoantibodies against GABA-A receptor (Gamma-amino butyric acid type A receptor) have been reported in patients with autoimmune encephalitis. Typical clinical features include encephalitis with seizures (including status epilepticus), confusion, disorientation, hallucinations, cognitive dysfunction. Lower titers have also been associated with Stiff person syndrome.  

Antibodies against GABA-A receptor are graded as Lower-risk antibodies with a frequency of <30% of underlying cancer and a positive result yields 0 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. 

References 
  • Petit-Pedrol M, Armangue T, Peng X et al. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterization of the antigen, and analysis of the effects of antibodies. Lancet Neurol. 2014;13(3):276‐286. PMID: 24462240  
  • Dalmau J et al. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr; 97(2): 839–887. PMID: 28298428  
  • Pollak TA, Lennox BR, Müller S et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. Lancet Psychiatry 2020;7(1):93‐108. PMID: 31669058.  
  • Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622  

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Vial

ENSKILD ANALYS 876

GABA-A receptor antikroppar

Indikation Misstanke om autoimmun encefalit. 

Metod Indirekt immunofluorescens. Metoden är ännu inte validerad för klinisk laboratorie rutin diagnostik. 

Svar Anges som negativ eller positiv med titer. 

Tolkning Autoantikroppar mot GABA-A receptor (Gamma-amino butyric acid type A receptor) har rapporterats hos patienter med autoimmun encefalit. Typiska symptom är krampanfall (inklusive status epileptikus), kognitiv påverkan med desorientering och hallucinationer. Även Stiff person syndrom har rapporterats vid positiv reaktion i låga titer. 

Antikropparna riktade mot GABA-A receptor bedöms vara Lower-risk antibodies med en förekomst på <30% för en underliggande cancer och positivitet ger 0 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. 

Referenser 
  • Petit-Pedrol M, Armangue T, Peng X et al. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterization of the antigen, and analysis of the effects of antibodies. Lancet Neurol. 2014;13(3):276‐286. PMID: 24462240  
  • Dalmau J et al. Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System. Physiol Rev. 2017 Apr; 97(2): 839–887. PMID: 28298428  
  • Pollak TA, Lennox BR, Müller S et al. Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin. Lancet Psychiatry 2020;7(1):93‐108. PMID: 31669058. 
  • Graus F, et al. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm. 2021 May 18;8(4):e1014. PMID: 34006622 

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