INDIVIDUAL TEST 878
Sez6L2 Antibodies (IgG)
Indication
Suspicion of autoimmune encephalitis
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Cell-based assay (CBA), indirect immunofluorescence (IIF)
Reference interval
Serum: <1:10 negative
CSF: negative
Result
Results are reported as negative or positive. A positive result is followed by a titer (serum).
Interpretation
Sez6L2 is highly expressed in the cerebellum and hippocampus. Antibodies against Sez6L2 have been reported in various neurological symptoms, usually cerebellar ataxia, dysarthria, and extrapyramidal symptoms, but cognitive impairment and epilepsy have also been described.
References
- Kather A et al. Neurol Res Pract. 2022. Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature. PMID: 36310162
- Landa J et al. Neurol Neuroimmunol Neuroinflamm. 2020. Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects. PMID: 33144342
- Yaguchi H et al. J Neurol. 2018. Anti-Sez6l2 antibody detected in a patient with immune-mediated cerebellar ataxia inhibits complex formation of GluR1 and Sez6l2. PMID: 29423613
- Mehdiyeva A et al. Neurol Neuroimmunol Neuroinflamm. 2022. SEZ6L2 Antibody-Associated Cerebellar Ataxia Responsive to Sequential Immunotherapy. PMID: 35031588
Last updated: 2025-12-05
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ENSKILD ANALYS 878
Sez6L2-antikroppar (IgG)
Indikation
Misstanke om autoimmun encefalit
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Cell-based assay (CBA), indirekt immunofluorescens (IIF)
Referensintervall
Serum: <1:10 negativt
Likvor: negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras (serum).
Tolkning
Sez6L2 uttrycks rikligt i cerebellum och hippocampus. Antikroppar mot Sez6L2 har rapporterats vid varierande neurologiska symptom, vanligen cerebellär ataxi, dysartri och extrapyramidala symptom, men även kognitiv påverkan och epilepsi har beskrivits.
Referenser
- Kather A et al. Neurol Res Pract. 2022. Anti-SEZ6L2 antibodies in paraneoplastic cerebellar syndrome: case report and review of the literature. PMID: 36310162
- Landa J et al. Neurol Neuroimmunol Neuroinflamm. 2020. Seizure-related 6 homolog like 2 autoimmunity: Neurologic syndrome and antibody effects. PMID: 33144342
- Yaguchi H et al. J Neurol. 2018. Anti-Sez6l2 antibody detected in a patient with immune-mediated cerebellar ataxia inhibits complex formation of GluR1 and Sez6l2. PMID: 29423613
- Mehdiyeva A et al. Neurol Neuroimmunol Neuroinflamm. 2022. SEZ6L2 Antibody-Associated Cerebellar Ataxia Responsive to Sequential Immunotherapy. PMID: 35031588
Senast uppdaterat: 2025-12-05