INDIVIDUAL TEST 884

Myelin oligodendrocyte glycoprotein (MOG) antibodies (ADEM)

IndicationSuspicion of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO).MethodIndirect immunofluorescens (IIF) in cells transfected with MOG.AnswerResults are given as positive or negative. A positive result is followed by a titer (serum).InterpretationMyelin oligodendrocyte glycoprotein is expressed on the myelin sheath. Increased levels of antibodies against MOG may occur at very low frequency in multiple sclerosis but should be tested in anti-aquaporin 4-negative patients where Neuromyelitis optica/Neuromyelitis optica spectrum disorders (NMO/NMOSD) is suspected.

Detection of antibodies against MOG has been found to be more sensitive in serum when compared to CSF. In patients with high levels of anti-MOG antibodies in blood, they can sometimes also be detected in CSF, suggesting passage of the antibodies from blood across the blood-brain barrier. The significance of anti-MOG antibodies in CSF is unclear.

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Neurology

ENSKILD ANALYS 884

Myelin oligodendrocyt glykoprotein/MOG-antikroppar (ADEM)

IndikationMisstanke om Multipel Skleros (MS) och Neuromyelitis Optica (NMO).MetodIndirekt immunofluorescens (IIF) med celler transfekterade med MOG.SvarResultatet anges som negativt eller positivt. Positivt resultat titreras (serum).TolkningMyelin oligodendrocyt glykoprotein uttrycks på ytan av myelin. Förhöjd nivå av IgG-antikroppar mot MOG är ovanligt vid multipel skleros (MS) men kan påvisas i en del fall med anti-AQP4-negativ Neuromyelitis optica/Neuromyelitis optica spectrum disorders (NMO/NMOSD).

Detektion av antikroppar mot MOG har högre sensitivitet i serum jämfört med CSF. Anti-MOG antikroppar har detekterats i CSF hos seropositiva patienter med höga antikroppstitrar, vilket föreslår en perifer produktion av anti-MOG IgG. Diagnos relevans av anti-MOG antikroppar i CSF är oklart.

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Neurologi