Suspicion of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO).
Indirect immunofluorescence (IIF) with MOG-transfected cells.
Results are given as positive or negative. A positive result is followed by a titer (serum).
Myelin oligodendrocyte glycoprotein is expressed on the myelin sheath. Increased levels of antibodies against MOG may occur at very low frequency in multiple sclerosis but should be tested in anti-aquaporin 4-negative patients where Neuromyelitis optica/Neuromyelitis optica spectrum disorders (NMO/NMOSD) is suspected.
Detection of antibodies against MOG has been found to be more sensitive in serum when compared to CSF. In patients with high levels of anti-MOG antibodies in blood, they can sometimes also be detected in CSF, suggesting passage of the antibodies from blood across the blood-brain barrier. The significance of anti-MOG antibodies in CSF is unclear.
Antibodies against MOG are graded as Lower-risk antibodies with only 5 reported cases of underlying cancer and a positive result yields 0 points PNS score, according to Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
Last updated: 2024-06-18
Misstanke om Multipel Skleros (MS) och Neuromyelitis Optica (NMO).
Indirekt immunofluorescens (IIF) med MOG-transfekterade celler.
Resultatet anges som negativt eller positivt. Positivt resultat titreras (serum).
Myelin oligodendrocyt glykoprotein (MOG) uttrycks på ytan av myelin. Förhöjd nivå av IgG-antikroppar mot MOG är ovanligt vid multipel skleros (MS) men kan påvisas i en del fall med anti-AQP4-negativ Neuromyelitis optica/Neuromyelitis optica spectrum disorders (NMO/NMOSD).
Detektion av antikroppar mot MOG har högre sensitivitet i serum jämfört med CSF. Anti-MOG antikroppar har detekterats i CSF hos seropositiva patienter med höga antikroppstitrar, vilket föreslår en perifer produktion av anti-MOG IgG. Diagnos relevans av anti-MOG antikroppar i CSF är oklart.
Antikropparna riktade mot MOG bedöms vara Lower-risk antibodies med endast 5 rapporterade fall med en underliggande cancer och positivitet ger 0 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
Senast uppdaterat: 2024-06-18