INDIVIDUAL TEST 960
MuSK Antibodies (IgG)
Indication
Suspicion of Myasthenia Gravis (MG)
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
RIA
Reference interval
< 0.05 nmol/L negative
Result
Results are reported as negative or positive with a concentration.
Interpretation
Antibodies against MuSK are seen in approximately 40% of patients with myasthenia gravis (MG) lacking AChR antibodies. MuSK is a membrane protein in motor end plates and is important for the structure and function of AChR.
Wieslab also offers a test for antibodies against LRP4 which can be seen in 1-5% of patients with MG as well as in double-negative MG, i.e., without the presence of antibodies against AChR or MuSK.
References
- Skeie GO et al. J Neurol. 2010. Guidelines for treatment of autoimmune neuromuscular transmission disorders. PMID: 20402760
- Fichtner ML et al. Int Rev Neurobiol. 2025. Autoantibodies in myasthenia gravis. PMID: 40675742
- Keritam O et al. Front Immunol. 2024. A clinical perspective on muscle specific kinase antibody positive myasthenia gravis. PMID: 39703505
Last updated: 2025-10-09
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ENSKILD ANALYS 960
MuSK-antikroppar (IgG)
Indikation
Misstanke om myastenia gravis (MG)
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
RIA
Referensintervall
< 0.05 nmol/L negativt
Resultat
Resultat anges som negativt eller positivt med koncentration.
Tolkning
Antikroppar mot MuSK ses hos ca 40% av de patienter med myastenia gravis (MG) som saknar AChR-antikroppar. MuSK är ett membranprotein i motoriska ändplattor och har betydelse för uppbyggnad och funktion av AChR.
Wieslab erbjuder även analys av antikroppar mot LRP4 som kan påvisas 1–5% av MG patienter och även kan ses hos dubbelnegativ MG patienter dvs utan förekomst av antikroppar mot AchR eller MuSK.
Referenser
- Skeie GO et al. Eur J Neurol. 2010. Guidelines for treatment of autoimmune neuromuscular transmission disorders. PMID: 20402760
- Fichtner ML et al. Int Rev Neurobiol. 2025. Autoantibodies in myasthenia gravis. PMID: 40675742
- Keritam O et al. Front Immunol. 2024. A clinical perspective on muscle specific kinase antibody positive myasthenia gravis. PMID: 39703505
Senast uppdaterat: 2025-10-09