INDIVIDUAL TEST 970
Trib2 Antibodies
Indication
Suspicion of narcolepsy
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Radioimmunoprecipitation (RIP)
Reference interval
<10 negative, 10-15 borderline
Result
Results are reported as negative, borderline, or positive with a titer.
Interpretation
Antibodies against Trib-2 have been reported in up to 26 % of patients with narcolepsy and cataplexy, but the diagnosis is primary based on clinical symptoms, HLA-typing and hypocretin levels in CSF.
References
- Cvetkovic-Lopes V et al. J Clin Invest. 2010. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. PMID: 20160349
- Kawashima M et al. Sleep. 2010. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are Associated with Recent Onset of cataplexy. PMID: 20614846
- Toyoda H et al. Sleep. 2010. Anti-Tribbles homolog 2 autoantibodies in Japanese patient with narcolepsy. PMID: 20614847
- Winding A et al. J Autoimmun. 2014. A/H1N1 Antibodies and TRIB2 autoantibodies in narcolepsy patient Diagnosed in Conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010. PMID: 24485154
- Zhang Y et al. Mol Immunol. 2005. Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. PMID: 15950723
Last updated: 2025-12-05
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ENSKILD ANALYS 970
Trib2-antikroppar
Indikation
Misstanke om narkolepsi
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Radioimmunoprecipitation (RIP)
Referensintervall
<10 negativt, 10-15 gränsvärde
Resultat
Resultat anges som negativt, gränsvärde eller positivt med titer.
Tolkning
Antikroppar mot Trib-2 har rapporterats förekomma hos upp till 26% av patienter med narkolepsi och kataplexi, men i första hand baseras diagnosen på kliniska symtom, HLA-typning och hypocretin-nivåer i likvor.
Referenser
- Cvetkovic-Lopes V et al. J Clin Invest. 2010. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. PMID: 20160349
- Kawashima M et al. Sleep. 2010. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are Associated with Recent Onset of cataplexy. PMID: 20614846
- Toyoda H et al. Sleep. 2010. Anti-Tribbles homolog 2 autoantibodies in Japanese patient with narcolepsy. PMID: 20614847
- Winding A et al. J Autoimmun. 2014. A/H1N1 Antibodies and TRIB2 autoantibodies in narcolepsy patient Diagnosed in Conjunction with the Pandemrix vaccination campaign in Sweden 2009-2010. PMID: 24485154
- Zhang Y et al. Mol Immunol. 2005. Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display. PMID: 15950723
Senast uppdaterat: 2025-12-05