INDIVIDUAL TEST 986
Neurogranin
Indication
Suspicion of Alzheimer's disease and in memory examination
Sample material
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: frozen
- International: frozen
Method
ELISA
Reference interval
<245 ng/L normal
Result
Results are reported as normal or elevated with a concentration (ng/L).
Interpretation
Neurogranin is a postsynaptic protein that is important for memory function and is expressed in areas damaged by Alzheimer’s disease. Elevated levels can be seen in the early stages and are higher in Alzheimer's disease compared to other neurodegenerative diseases.
References
- Agnello L et al. Diagnostics (Basel). 2021. Neurogranin as a Reliable Biomarker for Synaptic Dysfunction in Alzheimer's Disease. PMID: 34943576
- Richter G et al. Neurobiol Aging. 2025. Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes. PMID: 40669105
- Das S et al. Alzheimer's Res Ther. 2024. The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's disease. PMID: 38355535
Last updated: 2025-12-01
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ENSKILD ANALYS 986
Neurogranin
Indikation
Misstanke om Alzheimers sjukdom eller vid minnesutredning
Provmaterial
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: fryst
- Internationellt: fryst
Metod
ELISA
Referensintervall
<245 ng/L normalt
Resultat
Resultat anges som normalt eller förhöjt med koncentration (ng/L).
Tolkning
Neurogranin är ett postsynaptiskt protein som är viktigt för minnesfunktion och uttrycks rikligt i de områden som drabbas av Alzheimers sjukdom. Förhöjda nivåer kan ses i tidigt skede och vanligtvis är nivån högre vid Alzheimers sjukdom jämfört med andra neurodegenerativa sjukdomar.
Referenser
- Agnello L et al. Diagnostics (Basel). 2021. Neurogranin as a Reliable Biomarker for Synaptic Dysfunction in Alzheimer's Disease. PMID: 34943576
- Richter G et al. Neurobiol Aging. 2025. Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes. PMID: 40669105
- Das S et al. Alzheimer's Res Ther. 2024. The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's disease. PMID: 38355535
Senast uppdaterat: 2025-12-01