INDIVIDUAL TEST 988
CXCL13
Indication
Suspicion of neuroborreliosis or neuroinflammation
Sample material
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: frozen
- International: frozen
Method
ELISA
Reference interval
< 7.8 ng/L
Result
Results are reported as normal or elevated with a concentration.
Interpretation
An elevated level of the chemokine CXCL13 is seen in neuroinflammation with B-cell infiltration. A strongly elevated level is typical of neuroborreliosis. Slight to moderate increased levels can often be seen in multiple sclerosis (MS) and other neuroinflammatory diseases.
References
- Muñoz-Sánchez G et al. Neurol Neuroimmunol Neuroinflamm. 2025. Cytokine and Chemokine Profiles in Anti-LGI1 Encephalitis: Markers of Severity and Outcome. PMID: 41115260
- Segal Y et al. Ann Clin Transl Neurol. 2025. CSF cytokine, chemokine, and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity. PMID: 39869499
- Magliozzi R et al. Brain Pathol. 2025. Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis. PMID: 39617422
Last updated: 2025-12-05
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ENSKILD ANALYS 988
CXCL13
Indikation
Misstanke om neuroborrelios eller annan neuroinflammation
Provmaterial
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: fryst
- Internationellt: fryst
Metod
ELISA
Referensintervall
< 7.8 ng/L
Resultat
Resultat anges som normal eller förhöjd nivå med koncentration.
Tolkning
Förhöjd nivå av kemokinet CXCL13 i likvor ses vid neuroinflammation med infiltration av B-celler. Kraftigt förhöjd nivå är typiskt vid neuroborrelios. Lätt-måttligt förhöjda nivåer förhöjningar kan ses vid multipel skleros (MS) och andra neuroinflammatoriska sjukdomar.
Referenser
- Muñoz-Sánchez G et al. Neurol Neuroimmunol Neuroinflamm. 2025. Cytokine and Chemokine Profiles in Anti-LGI1 Encephalitis: Markers of Severity and Outcome. PMID: 41115260
- Segal Y et al. Ann Clin Transl Neurol. 2025. CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity. PMID: 39869499
- Magliozzi R et al. Brain Pathol. 2025. Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis. PMID: 39617422
Senast uppdaterat: 2025-12-05