INDIVIDUAL TEST 989
Orexin (Hypokretin-1)
Indication
Suspicion of narcolepsy
Sample material
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
RIA
Reference interval
110-200 pg/mL borderline, >200 pg/mL normal
Result
Results are reported as normal, borderline or decreased with concentration.
Interpretation
Hypocretin-1 levels are usually considerably lowered in narcolepsy. The diagnosis is also based on the clinical symptoms and carriage of HLA-DQB1*0602.
References
- Lozano-Tovar S et al. Neurol Sci. 2025. Cerebrospinal-fluid Orexin-A levels in different neurocognitive disorders: a comparison study. PMID: 40198471
- Freeman SA et al. Semin Immunol. 2025. Unraveling the pathophysiology of narcolepsy type 1 through hypothesis-driven and hypothesis-generating approaches. PMID: 40373365
- Vringer M et al. Sleep Med Rev. 2024. Recent insights into the pathophysiology of narcolepsy type 1. PMID: 39241492
Last updated: 2025-12-05
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ENSKILD ANALYS 989
Orexin (Hypokretin-1)
Indikation
Misstanke om nakolepsi
Provmaterial
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
RIA
Referensintervall
110-200 pg/mL gränsvärde, >200 pg/mL normalt
Resultat
Resultat anges som normalt, gränsvärde eller nedsatt med koncentration.
Tolkning
Hypokretin-1 nivån är vanligen kraftigt sänkt vid narkolepsi. Diagnosen baseras även på kliniska symtom och bärarskap av HLA-DQB1*0602.
Referenser
- Lozano-Tovar S et al. Neurol Sci. 2025. Cerebrospinal-fluid Orexin-A levels in different neurocognitive disorders: a comparison study. PMID: 40198471
- Freeman SA et al. Semin Immunol. 2025. Unraveling the pathophysiology of narcolepsy type 1 through hypothesis-driven and hypothesis-generating approaches. PMID: 40373365
- Vringer M et al. Sleep Med Rev. 2024. Recent insights into the pathophysiology of narcolepsy type 1. PMID: 39241492
Senast uppdaterat: 2025-12-05