INDIVIDUAL TEST 996
GFAP Antibodies (IgG)
Indication
Suspicion of autoimmune CNS-diseases
Sample material
Serum
- Minim. volume: 0,5 mL
CSF
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: cold
Method
Indirect immunofluorescence (IIF)
Reference interval
Serum: <1:100 negative
CSF: negative
Result
Results are reported as negative or positive. A positive result is followed by a titer (serum).
Interpretation
Autoantibodies against GFAp have been reported in autoimmune meningo-encephalo-myelitis. Epileptic seizures, meningismus, headache, cognitive impairment, and myelopathy are the most common. Optic neuritis and area postrema syndrome have also been reported.
Antibodies against GFAp are graded as Lower-risk, with an approximate underlying cancer frequency of 20%. According to the “Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes” (see ref. below), positive results have a 0-point PNS score.
References
- Kunchok A et al. Curr Opin Neurol. 2019. Autoimmune glial fibrillary acidic protein astrocytopathy. PMID: 30724768
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Chukwuocha I et al. Clin Neurol Neurosurg. 2025. Autoimmune glial fibrillary acidic protein astrocytopathy - The benefit of early diagnosis and initiation of therapy: A case report. PMID: 40669121
- Gravier-Dumonceau A et al. Neurology. 2022. Glial Fibrillary Acidic Protein Autoimmunity: A French Cohort Study. PMID: 34799461
Last updated: 2025-12-02
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ENSKILD ANALYS 996
GFAP-antikroppar (IgG)
Indikation
Misstanke om autoimmun CNS-sjukdom
Provmaterial
Serum
- Minim. volym: 0,5 mL
Likvor
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: kylt
Metod
Immunofluorescens (IIF)
Referensintervall
Serum: <1:100 negativt
Likvor: negativt
Resultat
Resultat anges som negativt eller positivt. Positivt resultat titreras (serum).
Tolkning
Autoantikroppar mot GFAp har rapporterats vid autoimmun meningo-encefalo-myelit. Epileptiska anfall, meningism, huvudvärk, kognitiv påverkan och myelopati är vanligast. Även optikusneurit och area postrema syndrom har rapporterats.
Antikropparna riktade mot GFAp bedöms vara Lower-risk antibodies med en förekomst på ca 20% för en underliggande cancer och ger 0 poäng i PNS score enligt Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes.
Referenser
- Kunchok A et al. Curr Opin Neurol. 2019. Autoimmune glial fibrillary acidic protein astrocytopathy. PMID: 30724768
- Graus F et al. Neurol Neuroimmunol Neuroinflamm. 2021. Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes. PMID: 34006622
- Chukwuocha I et al. Clin Neurol Neurosurg. 2025. Autoimmune glial fibrillary acidic protein astrocytopathy - The benefit of early diagnosis and initiation of therapy: A case report. PMID: 40669121
- Gravier-Dumonceau A et al. Neurology. 2022. Glial Fibrillary Acidic Protein Autoimmunity: A French Cohort Study. PMID: 34799461
Senast uppdaterat: 2025-12-02