INDIVIDUAL TEST 997
Beta Amyloid Ratio 42/40
Indication
In memory investigation, Alzheimer's disease
Method
Chemiluminescence
Response
The result is reported as a ratio.
Reference interval: > 0.72 ( > 50 years of age).
Interpretation
Beta amyloid 40 is the most common variant of beta amyloid in CSF, while beta amyloid 42 predominates in senile plaques. Decreased ratio of Beta amyloid 42/40 is a strong marker of Alzheimer's disease and can be detected early in the disease progression, even before clinical dementia occurs.
References
- Hansson O, Lehmann S, Otto M, Zetterberg H, Lewczuk P. Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer's Disease. Alzheimers Res Ther. 2019;11(1):34. PMID: 31010420
- Dumurgier J, Schraen S, Gabelle A, et al. Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study. Alzheimers Res Ther. 2015;7(1):30. PMID: 26034513
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ENSKILD ANALYS 997
Beta Amyloid kvot 42/40
Indikation
Vid minnesutredning, Alzheimer’s sjukdom
Metod
Kemiluminescens
Svar
Svaret rapporteras som en kvot.
Referensintervall: >0.72 ( >50 års ålder).
Tolkning
Beta amyloid 40 är den mest förekommande varianten av beta amyloid i likvor, men beta amyloid 42 dominerar i senila plaques. Sänkt kvot Beta amyloid 42/40 i likvor kan påvisas redan tidigt i sjukdomsförloppet av Alzheimers sjukdom, även innan klinisk demens föreligger och är av värde för att urskilja Alzheimer från andra former av demens.
Referenser
- Hansson O, Lehmann S, Otto M, Zetterberg H, Lewczuk P. Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer's Disease. Alzheimers Res Ther. 2019;11(1):34. PMID: 31010420
- Dumurgier J, Schraen S, Gabelle A, et al. Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study. Alzheimers Res Ther. 2015;7(1):30. PMID: 26034513