Svar Life Science

March 26, 2020

Complement activation and transplantation

In recent years, there has been growing interest in the role of the complement system in transplantation medicine. Interestingly, the complement system is activated shortly after death occurs, which means that organs from deceased donors can contain complement components that trigger complement activation in the recipient. In addition, cold storage of organs awaiting transplantation can cause hypoxia, inflammation and tissue damage that activates the complement system and can contribute to graft loss and rejection.

March 26, 2020

Complement activation and transplantation

In recent years, there has been growing interest in the role of the complement system in transplantation medicine. Interestingly, the complement system is activated shortly after death occurs, which means that organs from deceased donors can contain complement components that trigger complement activation in the recipient. In addition, cold storage of organs awaiting transplantation can cause hypoxia, inflammation and tissue damage that activates the complement system and can contribute to graft loss and rejection.

The presence of complement components in the plasma of deceased donors have been found to result in poor post-transplantation outcomes. Furthermore, C5a and C5b-9 is commonly found in biofluids of organ recipients during rejection, further highlighting the importance of the complement system during transplantation. 

The exact mechanism behind complement activation during transplantation appears to be complex and is not well understood. However, there is emerging evidence to suggest that components of the lectin pathway may be important inducing factors. 

Targeting the complement system might be a promising therapeutic strategy to improve the quality of various donor organs. 

What we offer?

Svar has over 15 years’ experience of complement system assay development. Our complement system assays have been developed by our experienced scientists in close collaboration with key opinion leaders, to yield sensitive, reliable and easy-to-use products for the exploration of most aspects of the complement system.     

The Svar Complement activity biomarkers give valuable intelligence in several situations where one might suspect that complement activation plays a role in the disorder. They are developed to target the unique neoepitopes only presented at the complement component or complex when activated. 
 
Take advantage of our complement expertise and let us guide you on the Complement Pathway!

 

Learn more about our Complement Portfolio