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CD20 is a protein expressed on the surface of B-cells from an early phase of development until cell maturity. Although the physiological ligand and exact biological function of CD20 is still unknown, it is believed to act as a calcium ion channel in the cell membrane. CD20 is clinically interesting ... Read more
The epidermal growth factor receptor (EGFR) plays an important role in the signaling that directs the behavior of epithelial cells. It is one of four transmembrane growth factor receptor proteins that share similarities in structure and function. There are multiple ligands that bind to and activate ... Read more
Breast cancer is a major health problem with close to two million new cases diagnosed each year worldwide. In about 1 out of 5 cases, human epidermal growth factor receptor 2 (HER2) has been found to be overexpressed. HER2 is a membrane receptor that is required for normal development of many ... Read more
In the late 1800s, William B. Coley used crude bacterial extracts to treat tumor patients. He found that the extracts were effective in inducing tumor necrosis. However, patients treated with his extracts were also found to suffer from a severe systematic inflammatory reaction. One of the major ... Read more