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In the rapidly expanding field of gene therapy, ensuring safety and efficacy remains a primary challenge. Neutralizing antibodies (NAb) against adeno-associated virus (AAV) capsids can impede the success of treatments. This blog post explores strategies to overcome NAb challenges and introduces the ... Read more
Learn more about the process at Svar of designing, constructing, producing and validating a fit-for purpose potency assay for use in batch release of an AAV based gene therapy drug. In the Select Science editorial special feature "Advances in Drug Discovery", we describe the process of developing ... Read more
The right cell-based assay expertise can provide a clearer picture of what is actually occurring in the body. With the use of living cells, cell-based assays are able to produce more biologically relevant results, which is key to understanding a biotherapeutic. Although the use of living cells adds ... Read more
Gene therapy is a promising technology with the potential of helping some of the hundreds of millions of people that live with genetic disease worldwide. In recent years, there has been a surge in interest for the technology and there are a large number of ongoing clinical trials. We are witnessing ... Read more