June 30, 2025

AAV Safety Assay Platform: The Immunogenicity Trifecta - NAb, TAb & Complement

Gene therapy is transforming the way we can treat many diseases, but immune responses to AAV vectors remain a critical challenge. Whether you're screening for pre-existing immunity, validating your vector, or preparing for regulatory submission, you need reliable, actionable data-and a partner who understands the stakes. .

Today, we're proud to launch our comprehensive AAV Immunogenicity Assay Platform.

This new offering combines three powerful assays into a fully customized safety solution to help you move forward with clarity and confidence.

June 30, 2025

AAV Safety Assay Platform: The Immunogenicity Trifecta - NAb, TAb & Complement

Gene therapy is transforming the way we can treat many diseases, but immune responses to AAV vectors remain a critical challenge. Whether you're screening for pre-existing immunity, validating your vector, or preparing for regulatory submission, you need reliable, actionable data-and a partner who understands the stakes. .

Today, we're proud to launch our comprehensive AAV Immunogenicity Assay Platform.

This new offering combines three powerful assays into a fully customized safety solution to help you move forward with clarity and confidence.

Three Core Assays. One Seamless Solution.

AAV NAb (Neutralizing Antibodies)

Rapidly assess pre-existing immunity for key AAV serotypes (2, 5, 6, 8, 9) with our off-the-shelf products or get a customised assays for your specific vector.

AAV TAb (Total Antibodies)

Leverage the specificity of our tailored ELISA-based Total Antibody assays to assess pre-existing antibody-mediated immunity towards any serotype, including your own unique vector

AAV Complement Activation (New!)

 Detect AAV vector-associated complement system activation with our ELISA-based AAV COMPL assay to reduce the risk of adverse events and gain a more complete and improved profile .

Each assay is available on demand or can be fully integrated into a custom solution tailored to your vector, indication, and development stage.

 

 

Build the Solution You Need

Our platform is designed for flexibility. Whether you're a biotech innovator, CRO, CDMO, or academic team, we offer:

  • Custom assay development using wild-type or engineered AAV vectors
  • Method development and validation aligned with regulatory expectations
  • Sample analysis and reporting to support INDs, clinical trials, and manufacturing
  • Scientific consultation to help you interpret results and plan next steps

 

Why Svar?

  • Speed: Off-the-shelf assays for rapid deployment
  • Flexibility: Tailored solutions for unique vectors and study designs
  • Expertise: A partner who understands your science and your pressure
  • Compliance: Robust data to meet regulatory expectations

Whether you need an established assay or a fully customized solution, we're ready to help. 

Contact us to get started