WIESLAB® Complement System Alternative Pathway - IVD

COMPLAP330

Assess specific activation and integrity of the complement alternative pathway with this functional ELISA, ideal for investigations into suspected complement deficiencies and dysfunctions, as well as in more extensive complement system profiling in clinical diagnostics.

  • Reliable, objective, and easy-to-interpret results
  • Results in just a few hours
  • Robust assay performance with low variability between users
  • Developed by our in-house experts in collaboration with key opinion leaders
  • Ready-to-use reagents for a streamlined workflow
  • High diagnostic sensitivity and specificity, ensuring accurate identification of complement deficiencies
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WIESLAB® Complement System Alternative Pathway - IVD

Product Overview

The WIESLAB® Complement System Alternative Pathway kit is an immunoassay for the qualitative determination of complement function in human serum. The assay provides alternative complement pathway specific functional assessment, aiding in detection of alternative pathway deficiencies.

The Wieslab Complement assays combine the specific activation of a pathway with the use of labeled antibodies specific for TCC (C5b-9), detecting a neoepitope of the Terminal Complement Complex, produced as the result of complement activation. The amount of detected TCC is proportional to the functional activity of the complement pathway in the sample.

By specifically only detecting de novo generated TCC, the Wieslab Complement System Alternative Pathway kit provides qualitative results of alternative pathway function, demonstrating if the pathway is preserved or deficient.

This product is also available as research use only - Product code: COMPLAP330RUO.

What's in the box?

  • One frame with break-apart wells (12x8)
  • 35 mL Diluent AP
  • 13 mL Conjugate
  • 13 mL Substrate solution
  • 30 mL Wash solution 30x concentrated
  • 0,2 mL Negative control (NC) containing human serum
  • 0,2 mL Positive control (PC) containing freezed dried human serum

Please note: All reagents in the kit are ready for use except washing solution and controls. The reagents should be stored at 2-8° C except the positive control. The positive control must be stored at -20°C.

Specifications

Product code COMPLAP330
Size 96 wells
Technology ELISA
Detection system ALP/pNPP read at 405 nm
Regulatory status IVD, CE labeled
Assay time 2h