WIESLAB® Complement System Classical Pathway - IVD

COMPLCP310

Assess specific activation and integrity of the complement classical pathway with this functional ELISA, ideal for investigations into suspected complement deficiencies and dysfunctions, as well as in more extensive complement system profiling in clinical diagnostics.

Reliable, objective, and easy-to-interpret results
Results in just a few hours
Robust assay performance with low variability between users
Developed by our in-house experts in collaboration with key opinion leaders
Ready-to-use reagents for a streamlined workflow
High diagnostic sensitivity and specificity, ensuring accurate identification of complement deficiencies

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WIESLAB® Complement System Classical Pathway - IVD

Product Overview

The WIESLAB® Complement System Classical Pathway is an immunoassay for the qualitative or semi-quantitative determination of complement function in human serum. The assay provides classical complement pathway specific functional assessment, aiding in detection of classical pathway deficiencies.

The Wieslab Complement Classical Pathway assay combines the specific activation of the pathway with the use of labeled antibodies specific for TCC (C5b-9), detecting a neoepitope of the Terminal Complement Complex, produced as the result of complement activation. The amount of detected TCC is proportional to the functional activity of the complement pathway in the sample.

By specifically only detecting de novo generated TCC, the Wieslab Complement System Classical Pathway kit provides qualitative or semi-quantitative results of classical pathway function, demonstrating if the pathway is preserved or deficient.

This product is also available as research use only - Product code: COMPLCP310RUO.

What's in the box?

One frame with break-apart wells (12x8)
2 x 35 mL Diluent CP
13 mL Conjugate
13 mL Substrate solution
30 mL Wash solution 30x concentrated
0,2 mL Negative control (NC) containing human serum
Lyophilized positive control (PC) containing human serum
Lyophilized activity control (AC) for semi-quantitative application, containing human serum

Please note: All reagents in the kit are ready to use except wash solution and controls. The reagents should be stored at 2-8° C. The positive control and the activity control should be stored at -20° C upon arrival. The reconstituted positive control and activity control should be stored at –70° C and may be thawed once.