Biomarker testing

Over 250 immunology markers at your service

Biomarkers are molecules found in the body that serve as indicators of a state, a disease or a condition. In drug development, biomarkers can serve as surrogates for the assessment of candidate drugs, where they can be used to validate targets, prove mechanisms of action, predicting efficacy and finding potential toxicity.
 

A biomarker service tailored to your needs

We offer you a complete biomarker service tailored to your drug development project. In addition to practical, technical and scientific support, Wieslab Bioanalytical Services can help you from start to finish in finding the optimal solution that fits your project needs and budget. We know that each project has unique requirements that need to be catered to when forming a project strategy.

Our expert service scientists in combination with our portfolio of over 250 immunology markers put us in a unique position to perform sample analysis of biomarker protein concentration levels in nonclinical and clinical settings that meet your expectations concerning reporting times, sample handling and storage conditions.

 

What are biomarkers?

Biomarkers may indicate either normal or diseased processes in the body and can assist in early diagnosis, disease prevention, drug target identification, drug response and more. There are two major types of biomarkers: biomarkers of exposure, which are used in risk prediction, and biomarkers of disease, which are used in screening and diagnosis and monitoring of disease progression.

A biomarker can be used as a decision base for a number of areas in the Clinical Protocol, e.g.:

  • Diagnostic – help to diagnose the disease
  • Prognostic – prediction of future disease
  • Predictive – identification of patients, who will benefit from the treatment.

Biomarker research is a tool used to improve the development of pharmaceuticals and understanding of disease. It involves the analysis of biomolecules (such as DNA, RNA, proteins, and lipids), or other measurements in relation to clinical endpoints of interest. 

Biomarkers and drug development

Biomarker research is being used by the pharmaceutical industry to streamline the drug development process.

Some biomarkers are used as substitutes or “surrogates” for safety or efficacy endpoints in clinical trials particularly where clinical outcomes or events cannot practically or ethically be measured. By using biomarkers to assess patient response, ineffective drug candidates may be terminated earlier in the development process in favor of more promising drug candidates.

Biomarker research can be influential across all phases of drug development, from drug discovery and preclinical evaluations to clinical development and post-marketing studies.

Further more, biomarkers are being used to optimize clinical trial designs and outcomes by identifying patient populations that are more likely to respond to a drug therapy or to avoid specific adverse events.

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