January 27, 2021

How to identify adverse effect in drug development

Every drug can produce some kind of unwanted effects – ranging from mild to severe – in addition to its intended effect

January 27, 2021

How to identify adverse effect in drug development

Every drug can produce some kind of unwanted effects – ranging from mild to severe – in addition to its intended effect

As adverse effects can result in hospitalization or in worst case even death, and naturally have a severe impact on the success of any drug development project -  it is important to identify them as early as possible in the development process.

Hence it is common practice in drug development to try to predict adverse effects before they happen in patients – typically using animal toxicology studies. However, since the results of these studies are not always easily transferrable to humans, use of in vitro assay data has gain traction as a powerful way of complementing animal studies.

We can help you avoid unpleasant surprises

This is where Svar Life Science comes in. This quarter we are putting the spotlight on how we, with our service offering and product portfolio, can help to identify adverse effects.

We offer a wide range of in vitro products and services that can be used to determine, monitor, and predict adverse effects to ensure that safe and effective drugs can be developed.

How we can help in the study of adverse effects in drug development

Helping you to assess neutralizing activity against viral AAV vectors

  • Tailored cell-based system to identify and quantify Nabs 
  • Bioanalytical Services supporting NAb projects for both gene therapy and other drug related projects

Learn more

Securing a safe and efficient drug by determining and assessing undesirable immunogenicity effects

  • Multi-tiered approach in compliance with regulatory Guidelines
  • Support in pre-clinical and clinical studies
  • Detection and confirmation of Anti-Drug Antibodies (ADAs) and Neutralizing Antibodies (NAbs)
  • Assessement by regular ligand binding assays and detection of NAbs on a functional cell-based assay

Learn more

Wieslab Bioanalytical Servcies – Answering to the complexities of large molecules

Watch the video to find out how the Wieslab Bioanalytical Services can help facilitate your work and speed up your drug development process. Watch Movie

Monitoring adverse effects in the complement system

  • Biomarker assays - for detection of complement activation or dysregulation in the complement system.
  • Functional assays - for analyses of all three pathways
  • Cell-based assays - iLite® cell-based functional reporter-gene assay
  • Flexi Solutions - for flexible assay setup on automated platforms

Learn more

Solutions for the study of antibody effector functions

  • Smart Fc receptor-bearing ADCC effector cells
  • Ready-to-use positive & negative target Cells for targets such as CD20, EGFR, HER2, mTNF-alpha, mVEGF etc.
  • Partner up with us and get a full-service solution

Learn more