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iLite the way

We have extensive experience developing cell-based reporter-gene assays using our proprietary iLite technology. These assays are ideal for quantifying drug potency, detecting NAbs, and assessing biologically relevant functionality in biopharmaceutical development.

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iLite the way

Luciferase Reporter Assays

Svar’s functional cell-based bioassays use our proprietary iLite® technology, a cleverly engineered system with target-induced reporter gene readout. They offer ease of use and robustness and can be developed for virtually any pharmaceutical target. Most of our cell-based reporter-gene assays come with a secondary reporter gene that acts as an internal control, compensating for differences in cell number and matrix effects.

iLite Cell-Based Reporter Gene Assays

We offer iLite cell-based reporter gene assays for a wide range of targets or custom-made for your target of choice. Regardless of what assay you select, you will get:

  • High sensitivity and large dynamic range
  • "Assay-ready" format for rapid and convenient use
  • Reproducible and biologically relevant results  
  • Reduced assay variability and higher reproducibility compared to cells in culture

Our Luciferase Reporter Assays

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ALL Interleukines Growth Factors Complement Hormones Cytokines Toll-like
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BM4023

iLite® IL-23 Assay Ready Cells

Precise measurement of IL-23-induced signaling in a cell-based context

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4023 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Interleukines |
BM3044

iLite® TNF-alpha Assay Ready Cells

Reproducible, cell-based quantification of TNF-α bioactivity. Ideal for functional testing of anti-TNF therapeutics and mechanism-of-action studies

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM3044 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Cytokines |
BM4073

iLite® C3a Assay Ready Cells

Quantitative measurement of complement C3a activity in a cell-based format

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4073 | Luciferase Reporter Assay | Complement | Cell-based reporter gene assay | Luminescence | Complement Products |
BM4075

iLite® C5a Assay Ready Cells

Quantitative measurement of complement C5a activity in a cell-based format

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4075 | Luciferase Reporter Assay | Complement | Cell-based reporter gene assay | Luminescence | Complement Products |
BM3071

iLite® FGF-21 Assay Ready Cells

Cell-based measurement of FGF-21 signaling, supporting metabolic research and development of FGF-21 analogs or mimetics

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM3071 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Growth Factors |
BM4055

iLite® G-CSF Assay Ready Cells

Reliable cell-based quantification of G-CSF activity, supporting biosimilar development and batch consistency testing

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4055 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Growth Factors |
BM4050

iLite® GM-CSF Assay Ready Cells

Functional quantification of granulocyte-macrophage colony-stimulating factor activity

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4050 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Growth Factors |
BM4080

iLite® hCG Assay Ready Cells

A sensitive, cell-based method for quantifying hCG bioactivity

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4080 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Hormones |
BM4012

iLite® IL-12 Assay Ready Cells

Functional, cell-based quantification of IL-12 signaling

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4012 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Interleukines |
BM4002

iLite® IL-2 Assay Ready Cells

Sensitive quantification of IL-2 activity or inhibition

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4002 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Interleukines |
BM4061

iLite® IL-6 Assay Ready Cells

Reproducible, cell-based detection of IL-6 bioactivity

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4061 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Interleukines |
BM3060

iLite® Insulin Assay Ready Cells

Robust, quantitative measurement of insulin receptor activation, facilitating characterization of insulin analogs and biosimilars

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM3060 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Hormones |
BM4052

iLite® RANKL Assay Ready Cells

Precise quantification of RANKL activity or blockade in a cell-based system

CELL-BASED
arrow
Cell-based reporter gene bioassay | Functional Bioassays | BM4052 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Cytokines |
BM4025

iLite® TLR4 Assay Ready Cells

Detection of TLR4-mediated NF-κB signaling

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4025 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Toll-like receptors |
BM6069

iLite® TLR9 Assay Ready Cells

Cell-based measurement of TLR9 pathway activation

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM6069 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Toll-like receptors |
BM4044

iLite® TNF-alpha Xcel Assay Ready Cells

Pre-qualified and assay-ready, these cells provide rapid and sensitive detection of TNF-α activity

CELL-BASED
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Cell-based reporter gene bioassay | Functional Bioassays | BM4044 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Cytokines |
BM4049

iLite® Type I IFN FAST Assay Ready Cells

Accelerated quantification of type I interferon signaling with a shortened incubation time

CELL-BASED
arrow
Cell-based reporter gene bioassay | Functional Bioassays | BM4049 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Cytokines |
BM4021

iLite® VEGF Assay Ready Cells

Quantification of vascular endothelial growth factor activity with high sensitivity

CELL-BASED
arrow
Cell-based reporter gene bioassay | Functional Bioassays | BM4021 | Luciferase Reporter Assay | Cell-based reporter gene assay | Luminescence | Growth Factors |

Didn't find what you were looking for?

We offer products customized to your needs. Our custom iLite® reporter-gene assays can be adapted to almost any target. We also offer custom ELISA plates and other products. In addition, you can take advantage of our service offerings and let us do the work for you.

Contact Us

iLite News

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Introducing the new iLite® C3a Assay Ready Cells

Introducing the new iLite® C3a Assay Ready Cells

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Improved Speed and Accuracy in Immunogenicity Testing

Improved Speed and Accuracy in Immunogenicity Testing

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Transitioning to Second-Generation iLite Cells

Transitioning to Second-Generation iLite Cells

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iLite Downloads

previous
IL-6 Biology, Inhibitors & COVID-19

IL-6 Biology, Inhibitors & COVID-19

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Mechanism-linked Potency Assays Drive Gene Therapy Success

Mechanism-linked Potency Assays Drive Gene Therapy Success

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Addressing the Analytical Gaps in Modern Therapeutic Development

Addressing the Analytical Gaps in Modern Therapeutic Development

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Developing a Customizable Complement-Dependent Cytotoxicity Assay

Developing a Customizable Complement-Dependent Cytotoxicity Assay

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Partnering for Success in a New Era of Advanced Therapeutics

Partnering for Success in a New Era of Advanced Therapeutics

Read post
The Immune Response to AAV Gene Therapy

The Immune Response to AAV Gene Therapy

Read post
How to Design Potency Assays for Gene Therapy Projects

How to Design Potency Assays for Gene Therapy Projects

Read post
A Cell-Based ADCC Bioassay Comparison

A Cell-Based ADCC Bioassay Comparison

Read post
Quantification of the Neutralizing Antibody Response to Recombinant AAV Vectors

Quantification of the Neutralizing Antibody Response to Recombinant AAV Vectors

Read post
Svar Complement Assays: Analyzing How Drug Candidates Affect the Complement System

Svar Complement Assays: Analyzing How Drug Candidates Affect the Complement System

Read post
Assay Development in AAV Therapies: Engineering iLite® Cell Lines for Specific and Analytical Applications

Assay Development in AAV Therapies: Engineering iLite® Cell Lines for Specific and Analytical Applic...

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Measuring C5a With a Functional Bioassay

Measuring C5a With a Functional Bioassay

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Establishment of a Novel iLite® Reporter Gene Assay Response to Insulin Products

Establishment of a Novel iLite® Reporter Gene Assay Response to Insulin Products

Read post
Evaluation of iLite® ADCC Effector Cells Using Different CD20 Target Cells

Evaluation of iLite® ADCC Effector Cells Using Different CD20 Target Cells

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Development of an FGF21 iLite® Reporter Gene Cell Line

Development of an FGF21 iLite® Reporter Gene Cell Line

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20+
years of product development

All 3
complement pathways studied individually

<5h
assay time

265+
scientific paper references

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